A Global Record of Patients With Anal Squamous Cell Carcinoma With and Without HIV Infection (ACTION HIV)

Latin American Cooperative Oncology Group (LACOG)

Status: Enrolling

Conditions: Anal Squamous Cell Carcinoma; HIV Infections

Study type: Observational

Funder types: Other

Identifiers

NCT05328765

LACOG 0421

Details and patient eligibility

About

Due to the scarcity of data on prognostic and predictive influence on CCA, epidemiological studies evaluating these factors need to be developed in patients with CCA. Therefore, the investigators want to evaluate the profile of patients in the real world and from various parts of the world, describing prognostic factors such as CD4 dosage, time of HIV infection, evaluation of viral load, diagnosis of AIDS, geographic region of diagnosis and treatment, clinical staging, medications concomitant with QRT (risk of drug interactions), comorbidities (possible impact on dose-intensity), use of HAART, time of use of HAART, radiotherapy modality (conventional 3D vs Modulated Beam Intensity [IMRT], response to Nigro vs CTII regimens, as well as comparing clinical outcomes with patients without HIV infection.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 18 years of age or older
• Confirmed histological diagnosis of anal canal squamous cell carcinoma. Basaloid subtype is accepted
• Have underundered serological test for HIV infection
• Any clinical stage

Exclusion criteria

• Lack of data on treatments and clinical outcomes

Trial design

300 participants in 2 patient groups

With HIV Infection

Description:

Patients with CCA with HIV infection,

Without HIV Infection

Description:

Patients with CCA without HIV infection,