A Grapefruit Feeding Trial in Healthy, Overweight Adults
Status
Conditions
Treatments
Details and patient eligibility
About
Folklore has suggested that consuming grapefruit may promote weight control. Sparse data exist to support this hypothesis, though there is some evidence of health promotional effects regarding blood pressure and lipid profiles. The aims of this randomized controlled trial are to determine the role of grapefruit in:
- Reducing weight
- Reducing blood pressure
- Reducing inflammation
- Improving the lipid profile.
The investigators hypothesize that six weeks of daily consumption of grapefruit will reduce weight, blood pressure, and inflammation while improving the lipid profile in overweight, healthy adults.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Adults, men and premenopausal women
- BMI: 25-45 kg/m2
- Willing to maintain current exercise regimen (not to exceed 10 hours/week)
- Willing to follow a diet low in bioactive rich fruits and vegetables and with no citrus
Exclusion criteria
- History of chronic disease
- Metabolic disease
- Inflammatory disease
- High cholesterol (>225 mg/dL)
- Smoker
- Taking medications metabolized by the Cytochrome P450 3A enzyme
- History of alcohol or drug abuse
Trial design
Primary purpose
Allocation
Interventional model
Masking
85 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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