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A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents (ViraSafeRCT)

K

Ksana Health

Status

Begins enrollment this month

Conditions

Mental Health Disorder
Anhedonia
Suicide

Treatments

Behavioral: ViraSafe: Treatment pushes
Behavioral: BRITE

Study type

Interventional

Funder types

Other
Industry
NIH

Identifiers

NCT07348666
STUDY25040094
R44MH135605 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Digital tools, especially personal smartphones, are promising avenues to address these issues and can be used to increase engagement with effective interventions such as suicide safety planning. The BRITE suicide safety planning app was developed on evidence-based principles and has undergone rigorous formative development and effectiveness evaluations. However, to optimize its functionality, commercial viability, and scale its implementation, issues related to user engagement needed to be addressed. This 3 month Pragmatic Randomized Trial will evaluate the impact of the ViraSafe app-an enhanced version of the BRITE suicide safety planning app-on improving engagement with coping skills and safety planning among suicidal adolescents by comparing its intervention components to those of the original BRITE app.

Full description

ViraSafe is an augmented version of the BRITE app that integrates the BRITE coping skills and safety planning content into a module within the Vira behavior change platform. Vira, a digital behavior change platform developed by Ksana Health, consists of a smartphone app for patients, along with integrated web portals for practitioners and for healthcare administrators and supervisors. The platform collects self-report and passive data on smartphone usage patterns, such as language use, physical activity, sleep, social interactions, and screen time, and uses these insights to provide objective and continuous measurements of mental health indicators.

Upon downloading the Vira app and accessing the ViraSafe module, participants will complete a safety plan with their provider. Safety plan content will be editable and viewable throughout the intervention for both participants and their providers. Participants will be able to access the safety plan at any time in ViraSafe. Additionally, patients using ViraSafe will be prompted to complete a daily distress rating. ViraSafe uses automated algorithms (i.e., just in time adaptive intervention features) and user input from distress ratings to facilitate increased engagement with coping skills and pushes safety planning materials to users at periods of high risk (i.e., increases in emotional distress).

In addition to the just-in-time reminders (i.e., nudges) pushed automatically by the system, through the Vira Pro platform, practitioners can schedule just-in-time reminders (i.e., "nudges") to arrive in the user's phone to support their behavior change plan.

After undergoing study screening procedures and providing informed consent/assent, participants will complete the baseline assessment (60 minutes) which will occur virtually over video conference software or phone call.

Additional self-reports collected at patient visit will be requested through informed consent process as some overlap with what research team plans to administer. Self-reports will be retrieved for data analysis at the timepoints that align with the study timepoints. Self-reports will be administered by research staff if not available from a clinic's measurement-based care system.

Following Baseline assessments, participants will be randomized in a 1:1 allocation to receive ViraSafe or BRITE (50 in each arm). Randomization will be based on age, sex, and suicide symptoms. At a scheduled patient visit in their clinical settings, onboarding to assigned app will occur. Onboarding involves downloading their assigned app from Google Play Store or Apple App Store. Each app involves a trained clinician from their clinic setting collaboratively completing a safety plan. If a mental health clinician is not available for onboarding after Baseline, a research clinician will assist with onboarding.

At 1-month timepoint, participants will repeat the assessment interview (which will occur virtually over video conference software or phone call) and self-report measures with additional items assessing acceptability, usability, and satisfaction using the Technology Acceptance Model (TAM) and System Usability Scale (SUS) (total assessment duration: 60 minutes). At the 3-month timepoint, participants will repeat the assessment interview (which will occur virtually over video conference software or phone call) and self-report measures (total duration: 60 minutes).

20 adolescent participants or as many that are needed to reach saturation who received ViraSafe intervention arm will be selected to complete a qualitative exit interview to provide additional feedback on the intervention (60 minutes). The interview guide will be developed closer to the time of first exit interview and submitted for approval to the IRB prior to completing interviews.

Enrollment

100 estimated patients

Sex

All

Ages

13 to 24 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Youth (minors):

  • 13-17 years old
  • Suicide attempt in the last year and ideation in the past month
  • English fluency and literacy
  • Parent or legal guardian willing and able to legally provide informed consent
  • Receiving care at one of the study clinical settings with trained providers to onboard ViraSafe or BRITE safety plan

Youth (adults)

  • 18-24 years old
  • Recent suicide attempt or ideation with a plan
  • English fluency and literacy
  • Receiving care at one of the study clinical settings with trained providers to onboard ViraSafe or BRITE safety plan.

Exclusion criteria

Youth (minors):

  • Unable to read/understand English
  • Current manic or psychotic episode
  • Development disability precluding comprehension of study procedures
  • No routine access to a mobile phone, assessed by EHR review and during phone screen
  • No eligible parent or legal guardian to provide informed consent

Youth (adults):

  • Unable to read/understand English
  • Current manic or psychotic episode
  • Development disability precluding comprehension of study procedures
  • No routine access to a mobile phone, assessed by EHR review and during phone screen

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

100 participants in 2 patient groups

ViraSafe
Experimental group
Description:
The new augmented app that combines BRITE coping skills and safety planning into the Vira behavior change platform
Treatment:
Behavioral: ViraSafe: Treatment pushes
BRITE
Active Comparator group
Description:
The original BRITE app that promotes self-monitoring and self-management by providing strategies to avoid or cope with triggers for suicidal urges and has been rigorously tested in clinical trials
Treatment:
Behavioral: BRITE

Trial contacts and locations

3

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Central trial contact

Stephanie Stepp, PhD

Data sourced from clinicaltrials.gov

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