A Longitudinal Study in Parkinson's Disease (PD) Patients

Tel Aviv Sourasky Medical Center

Status: Unknown

Conditions: Parkinson's Disease

Treatments: Other: neurological exam

Study type: Observational

Funder types: Other

Identifiers

NCT01730599

TASMC-11-NG-0473

Details and patient eligibility

About

This is a longitudinal study in patients with Parkinson's Disease (PD) carriers of a genetic mutation - substitution of gly with ser in position 2019 (G2019S) in the leucine-rich repeat kinase 2 (LRRK2) gene. The purpose of this study is to explore the association between genetic mutations in the known genes and their influence on disease manifestation over few years of follow up

Enrollment: 200 estimated patients

Sex: All

Ages: 30+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• parkinson'd disease patients that already participated in a pasr cross sectional study

Exclusion criteria

• subjects with cognitive decline by the parameters defined in Diagnostic and Statistical Manual of Mental Disorders (DSM)- IV
• subjects with psychiatric disorder
• subjects unable to sign a consent form

Trial design

200 participants in 1 patient group

PD patients

Description:

PD patients carriers of the G2019S mutation in the LRRK2 gene

Treatment:

Other: neurological exam