A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients

Yonsei University

Status and phase: Completed; Phase 4

Conditions: Tracheal Extubation

Treatments: Drug: Remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT01152515

IRB 4-2010-0022

Details and patient eligibility

About

Tracheal extubation can be associated with hyperdynamic circulatory response. The investigators examined the effect of maintaining a remifentanil infusion on the cardiovascular response during extubation in propofol-remifentanil sedated patients after surgery.

Enrollment: 50 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age ≥ 20
2. Short term ventilator care after surgery in intensive care unit

Exclusion criteria

1. pneumonia
2. chronic obstructive lung disease
3. asthma
4. end stage renal disease
5. risk factors for aspiration

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

Control

No Intervention group

Description:

stopping of propofol and remifentanil infusion

Remifentanil

Active Comparator group

Description:

stopping of propofol and maintenance of remifentanil infusion

Treatment:

Drug: Remifentanil