A Metagenome-wide Association Study of Gut Microbiota in Gastrointestinal Non-Hodgkin's Lymphoma Patients

Shanghai Jiao Tong University

Status

Unknown

Conditions

Gastrointestinal Lymphoma

Treatments

Diagnostic Test: Metagenomic shotgun sequencing

Study type

Observational

Funder types

Other

Identifiers

NCT03930043

NHL-MGWAS

Details and patient eligibility

About

This is a observational study on the fecal microbiota in primary/secondary gastrointestinal lymphoma patients.

Full description

This observation study is aimed at investigating the gut microbiota alteration in gastrointestinal lymphoma (GIL) patients by performing metagenomic shotgun sequencing on GIL patients' fecal specimen. Before immuno-chemotherapy, the feces specimen of GIL would be collected and stored for further laboratory examination. This study would NOT alter the subsequential treatment of the patients.

Enrollment

160 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Gastrointestinal lymphoma with a clarified pathological diagnosis
De novo gastrointestinal lymphoma patients who haven't received chemotherapy
BMI in normal range

Exclusion criteria

Antibiotics or probiotics application within a month
Overweight (BMI≥25) or malnourished (BMI<18.5) patients
Patients who have been accepted gastrointestinal fistulation
Gastrointestinal patients with inflammatory bowel disease (IBD), colorectal carcinoma (CRC) or any other chronic intestinal disease
Patients infected by HIV