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A Methodological Open Label Cross-Over Controlled Study To Assess The Effect Of Drugs On Ventricular Repolarization and QT Interval At Fixed Heart Rate Under Autonomic Blockade

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Pfizer

Status and phase

Completed
Phase 1

Conditions

Patients With Pace Makers But no Evidence of Ischemic Heart Disease

Treatments

Drug: GTN
Drug: Moxifloxacin

Study type

Interventional

Funder types

Industry

Identifiers

NCT00174512
A9001226

Details and patient eligibility

About

To assess the effects of GTN on QT and QTc in subjects with And without atrial pacing. This will be done with and without autonomic blockade at two different pacing rates. Moxifloxacin effect on QT and QTc will also be assessed in atrially paced patients at two different pacing rates with and without autonomic blockade

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with pace-makers but otherwise normal ventricular function

Exclusion criteria

  • Nitrates, beta blockers

Trial design

Primary purpose

Educational/Counseling/Training

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

Trial contacts and locations

6

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Data sourced from clinicaltrials.gov

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