A Methodological Open Label Cross-Over Controlled Study To Assess The Effect Of Drugs On Ventricular Repolarization and QT Interval At Fixed Heart Rate Under Autonomic Blockade

Pfizer

Status and phase: Completed; Phase 1

Conditions: Patients With Pace Makers But no Evidence of Ischemic Heart Disease

Treatments: Drug: GTN; Drug: Moxifloxacin

Study type: Interventional

Funder types: Industry

Identifiers

NCT00174512

A9001226

Details and patient eligibility

About

To assess the effects of GTN on QT and QTc in subjects with And without atrial pacing. This will be done with and without autonomic blockade at two different pacing rates. Moxifloxacin effect on QT and QTc will also be assessed in atrially paced patients at two different pacing rates with and without autonomic blockade

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with pace-makers but otherwise normal ventricular function

Exclusion criteria

• Nitrates, beta blockers

Trial design

Primary purpose: Educational/Counseling/Training

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)