A Modified Esophagogastric Reconstruction Method After Laparoscopic Proximal Gastrectomy

Peking University

Status: Enrolling

Conditions: Anastomosis; Proximal Gastric Adenocarcinoma; Adenocarcinoma of Esophagogastric Junction

Treatments: Procedure: "arch-bridge-type" esophagogastric reconstruction after proximal gastrectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT05829213

2023YJZ11

Details and patient eligibility

About

The double-flap technique (DFT) is an effective digestive tract reconstruction method after proximal gastrectomy (PG) to reduce the incidence of postoperative reflux esophagitis. But its clinical application is restricted due to the technical complexity. Our surgical team devise a modified esophagogastric reconstructive method which we term the "arch-bridge-type" reconstruction based on the principle of DFT. The aim of this single-arm prospective study is to assess the safety and feasibility of the "arch-bridge-type" reconstruction after PG.

Full description

1. The lymphadenectomy is performed according to the Japanese Gastric Cancer Treatment Guidelines.
2. Transection of the esophagus is performed using a linear stapler 2cm away from the proximal end of the tumor.
3. Creating the seromuscular flap ("arch-bridge"):

(1) The stomach is resected by a linear stapling device. (2) A "匚" shaped seromuscularflap (3.0cm×4.0cm) is created utilizing electrocautery extracorporeally by dissecting submocosal and muscular layer of the anterior wall of the remnant stomach.

(3) The opening of the flap is interrupted sutured by 4-0 absorbable suture, then the "arch-bridge" is created.

4.The remnant stomach is then inserted into the abdominal cavity, and pneumoperitoneum is re-established to perform the intracorporeal anastomosis.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• histologically proven proximal gastric cancer or adenocarcinoma of esophagogastric junction
• diameter of the tumor less than 4cm
• ECOG performance status score ≤2
• no distant metastasis
• informed consent is signed

Exclusion criteria

• metastatic gastric cancer or metastatic adenocarcinoma of esophagogastric junction
• remnant gastric cancer
• patient requires emergency surgery

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

30 participants in 1 patient group

"arch-bridge-type" reconstruction arm

Experimental group

Description:

In this arm, patients will receive proximal gastrectomy and "arch-bridge-type" reconstruction.

Treatment:

Procedure: "arch-bridge-type" esophagogastric reconstruction after proximal gastrectomy