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A Modified Mathematical Model to Calculate Power Received by Mechanically Ventilated Patients With Different Etiologies

C

Changhua Christian Medical Foundation

Status

Unknown

Conditions

Acute Respiratory Distress Syndrome, Mechanical Ventilation, Respiratory Mechanics, Ventilator-induced Lung Injury

Treatments

Diagnostic Test: work of breath measurement and calculation

Study type

Observational

Funder types

Other

Identifiers

NCT04046380
108-CCH-IRP-081

Details and patient eligibility

About

Ventilator-induced lung injury is a common complication. The latest and most noticeable theory of its pathogenesis is called 'ergotrauma' by Gattinoni in 2016. The theory uses ventilator-imposed 'energy' or 'power' to encompass several known forms of injury-inducing factors such as pressure,volume, flow, rate, etc. However, to quantify power imposed by ventilator is no easy task in clinical practice. So, Gattinoni proposed a mathematical formula for easy power calculation. However, Gattinoni did not compare the difference between various etiologies of acute lung injury. We will enroll 100 patients (50 with acute respiratory distress syndrome and 50 with normal lung). The ventilator-imposed power at various tidal volume (6, 8, 10 ml/Kg) and positive end-expiratory pressure (5, 10 cmH2O) will be calculated by the formula. The area enclosed by hysteresis of pressure-volume curve, and hence the work it implies, will be measured as a standard. Our study will aim to compare the formula in different patient groups and in Taiwanese people.

Enrollment

100 estimated patients

Sex

All

Ages

20 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Intubated patients aged 20 to 90 years old

Exclusion criteria

  • Fraction of inspired oxygen (FiO2) higher than 60%
  • Acute physiology and chronic health evaluation (APACHE) II score more than 30
  • Plateau pressure or peak airway pressure more than 30 cmH2O
  • High risk for barotrauma
  • Unstable hemodynamic status
  • Under airway pressure release ventilation or high frequency oscillation ventilation therapy
  • Under extra-corporeal membrane oxygenation support
  • On prone position

Trial design

100 participants in 2 patient groups

normal lungs
Treatment:
Diagnostic Test: work of breath measurement and calculation
Acute respiratory distress syndrome (ARDS) group
Treatment:
Diagnostic Test: work of breath measurement and calculation

Trial contacts and locations

1

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Central trial contact

Shin Hwar Wu

Data sourced from clinicaltrials.gov

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