A Multi-center Study to Determine the Prevalence and Influence of Pertussis on COPD Exacerbation in Shenzhen

Southern University of Science and Technology

Status: Unknown

Conditions: Pertussis; COPD Exacerbation

Treatments: Procedure: Throat swab; Procedure: Blood sample; Other: Data collection

Study type: Observational

Funder types: Other

Identifiers

NCT04694430

WLW-COPD-Pertussis

Details and patient eligibility

About

A prospective, multi-center, observational clinical trail. Aim to evaluate the real incidence of chronic obstructive pulmonary disease (COPD) pertussis and the impact of pertussis on COPD exacerbation.

Full description

1. Investigate the incidence and epidemiological characteristics of pertussis infection in COPD population.
2. To explore the relationship between pertussis infection and COPD exacerbation.

Enrollment: 500 estimated patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of acute COPD

Exclusion criteria

• Major diseases except COPD; Significant abnormality in laboratory examination; Clinical diagnosis of lung cancer, bronchiectasis, pneumoconiosis or other simple restrictive ventilation dysfunction; Patients with a history of asthma, allergic rhinitis, or a blood eosinophil count of 2600/mm3 (0.6x10^9/L) within 4 weeks; Currently suffering from active tuberculosis; Patients with life-threatening pulmonary embolism, or al-antitrypsin deficiency, or cystic fibrosis; Patients who have undergone lung resection.

Trial design

500 participants in 2 patient groups

Severe exacerbation of COPD

Description:

N = 250

Treatment:

Procedure: Throat swab

Procedure: Blood sample

Other: Data collection

Mild and moderate exacerbations of COPD

Description:

N = 250

Treatment:

Procedure: Throat swab

Procedure: Blood sample

Other: Data collection