A Multi-omics Study of Adenomyosis

Lei Li

Status: Unknown

Conditions: Metabolomics; Genomics; Endometriosis; Adenomyosis; Eutopic Endometrium; Transcriptomics; Ectopic Endometrium

Treatments: Combination Product: A multi-omics analysis

Study type: Observational

Funder types: Other

Identifiers

NCT03742843

AM-OMICS

Details and patient eligibility

About

This study aims to analyze the multi-omics results between eutopic endometrium, adenomyosis and endometriosis of patients diagnosed of adenomyosis with and without endometriosis. The multi-omics profiles include whole exome sequencing, analysis of transcriptomics and metabolomics. A comprehensive multi-omics will reveal the pathogenesis of adenomyosis.

Enrollment: 200 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed adenomyosis and/or endometriosis
• Signed an approved informed consents
• Feasible for biopsy

Exclusion criteria

• Not meeting all of the inclusion criteria

Trial design

200 participants in 3 patient groups

Group of adenomyosis

Description:

Patients with adenomyosis with or without endometriosis

Treatment:

Combination Product: A multi-omics analysis

Group of endometriosis

Description:

Patients with endometriosis without adenomyosis

Treatment:

Combination Product: A multi-omics analysis

Group of control

Description:

Patients without adenomyosis or endometriosis

Treatment:

Combination Product: A multi-omics analysis