A Multicenter Prospective Cohort Study Study of CLAG Regimen in Acute Myeloid Leukemia Patients With First-induction Failure

Nanfang Hospital, Southern Medical University

Status: Not yet enrolling

Conditions: AML

Treatments: Combination Product: CLAG

Study type: Observational

Funder types: Other

Identifiers

NCT05875649

NEFC-2023-162

Details and patient eligibility

About

Most of patients with acute myeloid leukemia achieved complete remission (CR) after primary induction chemotherapy, there were 20-30% patients without CR after first-induction. It was uncertain how to treat these patients. It was investigated in our study that these patients were re-induced with CLAG Regimen. The CR ratio, overall survival (OS) and relapsed-free survival (RFS) was statistically analysed in these patients.

Enrollment: 137 estimated patients

Sex: All

Ages: 14 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute myeloid leukemia patients with first-induction failure

Exclusion criteria

• Acute myeloid leukemia patients with serious infection and organ dysfunction.

Trial design

137 participants in 1 patient group

Group

Description:

Acute myeloid leukemia patients with first-induction failure

Treatment:

Combination Product: CLAG