A Neonatal Bimodal MR-CT Head Template (Biomodal)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Magnetic Resonance Imaging

Treatments: Other: CTscan and MRI images

Study type: Observational

Funder types: Other

Identifiers

NCT03674034

PI2017_843_0047

Details and patient eligibility

About

This is a retrospective study based on the images contained in the database of the University Hospital of Amiens. There is no further examination. Electroencephalography (EEG) and Near-Infrared Spectroscopy (NIRS). These sources are widely used to specify the source of certain evoked potentials or to better define the sources of epileptic graphoelements, especially in the pre-surgical assessment of refractory epilepsies.

It is therefore important that these regions are more widely available in the constitution of the world, and that they are suitable for use in the design of new technologies. Although MRI is the gold standard for soft tissue segmentation, it is not suitable for bone extraction; especially in the newborn or the bone is very thin. On the other hand, CTscan is an excellent method for extracting bone. The contrast between bone and soft tissue is excellent. In this case, with the CTscan, the fontanelles are identified as discontinuities between the images of the temporal scales.

Full description

Magnetic resonance imaging (MRI) and brain scan (CT Scan) are the two main modalities of structural brain imaging that are widely used in routine practice. The extraction of bone from MRI and CTscan images is an important step in the segmentation of the different tissues of the subjects' heads. It is indeed necessary to know precisely the electrical characteristics (conductivities) and optical (absorption, diffraction) of tissues (skin, bone, LCS, gray matter and white matter), or by electric currents or by photons. One of the major problems is the one that is not very poorly visualized in MRIs in CTscan, the bone is well individualized and that inversely the various brain structures are difficult to extract. This justifies the fact of performing a coregistration of images obtained in MRI and CTscan.

The skull of the newborn is an inhomogeneous structure. The fontanelles are invisible in MRI and identifiable in CTscan.

Electroencephalography (EEG) and Near-Infrared Spectroscopy (NIRS). These sources are widely used to specify the source of certain evoked potentials or to better define the sources of epileptic graphoelements, especially in the pre-surgical assessment of refractory epilepsies.

It is therefore important that these regions are more widely available in the constitution of the world, and that they are suitable for use in the design of new technologies.

Although MRI is the gold standard for soft tissue segmentation, it is not suitable for bone extraction; especially in the newborn or the bone is very thin. On the other hand, CTscan is an excellent method for extracting bone. The contrast between bone and soft tissue is excellent. In this case, with the CTscan, the fontanelles are identified as discontinuities between the images of the temporal scales.

Enrollment: 150 patients

Sex: Male

Ages: 1 day to 2 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children aged between 0 and 2 months new born at term
• with no structural abnormalities

Exclusion criteria

• infants > 2 months

Trial design

150 participants in 3 patient groups

term

Description:

50 CTscan and MRI images of children aged at term

Treatment:

Other: CTscan and MRI images

one month

Description:

50 CTscan and MRI images of children aged one month

Treatment:

Other: CTscan and MRI images

two months

Description:

50 CTscan and MRI images of children aged two months

Treatment:

Other: CTscan and MRI images