A New Delineation Approach for Oral Cavity, Oropharynx, Larynx and Hypopharynx in IMRT for Head and Neck Cancer

Hebei Provincial Hospital of Traditional Chinese Medicine

Status: Completed

Conditions: Radiotherapy; Oropharynx Abnormality; Head and Neck Cancer; Radiotherapy; Adverse Effect

Treatments: Radiation: oropharynx and "oropharyngeal mucosa"; Radiation: oropharynx; Radiation: "Oropharyngeal mucosa"

Study type: Interventional

Funder types: Other

Identifiers

NCT05539144

HebeiProvincial

Details and patient eligibility

About

The investigators tries a new method to delineating the oral cavity, oropharynx, larynx and hypopharynx, and use the head-and-neck region to test whether the method can to create a good IMRT plan, and alleviate the oral radiation injury, reduce the incidence of adverse reactions.

Full description

Purpose: To assess the dosimetric effect of new delineation approach for oral cavity, oropharynx, larynx and hypopharynx in intensity-modulated radiotherapy(IMRT) treatment planning for head and neck cancer.

Methods: Twenty head and neck cancer patients were treated by IMRT. Target volumes and several organs at risk were delineated with Corvus6．3 treatment planning system. An investigative IMRT plan was generated based on a standard treatment planning protocol, but used a new delineation approach for oral cavity, oropharynx, larynx and hypopharynx. Plans were exported to treatment planning system for quantitative analysis of dose volume parameters. Variables assessed included: maximum oral cavity, oropharynx, larynx and hypopharynx dose, equivalent uniform dose of the oral cavity, oropharynx, larynx and hypopharynx (EUD), mean oral cavity, oropharynx, larynx and hypopharynx dose, mean organs at risks (OARs) doses, and dose homogeneity inside the target volumes.

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Enrollment: 8 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with previously untreated of the head and neck cancer who received definitive IMRT at our institution

Exclusion criteria

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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8 participants in 3 patient groups

"Oropharyngeal mucosa" as OARs

Experimental group

Description:

"Oropharyngeal mucosa" was delineated as OARs and limiting its dose

Treatment:

Radiation: "Oropharyngeal mucosa"

oropharynx as OARs

Experimental group

Description:

Oropharynx was delineated as OARs and limiting its dose

Treatment:

Radiation: oropharynx

Oropharynx and "oropharyngeal mucosa"as OARs

Experimental group

Description:

Oropharynx and "oropharyngeal mucosa" was delineated as OARs and limiting its dose

Treatment:

Radiation: oropharynx and "oropharyngeal mucosa"