A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)

Baskent University

Status: Completed

Conditions: Pneumoperitoneum; Acute Kidney Injury (Nontraumatic)

Treatments: Diagnostic Test: IGF-1

Study type: Interventional

Funder types: Other

Identifiers

NCT05612802

KA22/178

Details and patient eligibility

About

In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared. In our study, we aimed to investigate the effect of pneumoperitoneum applied on acute kidney injury in patients who underwent laparoscopic surgery. Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. Our study investigates whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.

Enrollment: 25 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients aged 18-70 years of both sexes
• ASA I-III Patients

Exclusion criteria

• Obesity,
• Chronic Kidney Disease,
• Chronic Renal Failure,
• Acute Renal Failure,
• Peripheral and ischemic vascular disease,
• Chronic Heart Failure,
• History of anaphylaxis,
• A-V block,
• Creatinine level >1.4,
• Neuromuscular disease,
• Malignant hypertension,
• Pyelonephritis,
• Urinary tract infectio,
• Severe inflammation/possible sepsis,
• Active malignancy,
• Patients with surgery reversion to laparotomy,
• Hemodynamic instability, need for vasopressors,
• Severe bleeding requiring blood transfusion,

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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25 participants in 1 patient group

IGF

Other group

Description:

Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. In our study, in order to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared.

Treatment:

Diagnostic Test: IGF-1