A New Supplement for the "Metabolic Syndrome"

University of Messina

Status: Completed

Conditions: Metabolic Syndrome

Treatments: Dietary Supplement: Sineos

Study type: Interventional

Funder types: Other

Identifiers

NCT03813914

Sineos-3

Details and patient eligibility

About

This study evaluates the effect of a combination of glycirrhizic acid, Cinnamomun Zeylanicum and corosolic acid for the treatment of metabolic syndrome. Participants receive the supplement or a placebo.

Full description

The supplement is composed by of a combination of glycirrhizic acid, Cinnamomun Zeylanicum and corosolic acid. They act in different way reducing insulin resistance, which is the main cause of metabolic syndrome. It was a randomized, controlled study involving 60 women with the metabolic syndrome following the criteria proposed by ATP III in 2015. Main outcomes were the improvement of the parameters that characterizes the metabolic syndrome, such as glucose and insulin levels, triglycerides, HDL-cholesterol and blood pressure.

Enrollment: 60 patients

Sex: Female

Ages: 45 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Postmenopausal women affected by Metabolic Syndrome, diagnosed by ATP 2015 criteria.

Exclusion Criteria: treatment with steroids or with hypoglycemic or anti-cholesterol drugs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups, including a placebo group

Sineos

Experimental group

Description:

Glycyrrhizic acid 38 mg + Cinnamomum Zeylanicum 150 mg + corosolic acid 480 mcg 2 pills/day for 3 months

Treatment:

Dietary Supplement: Sineos

Placebo comparator

Placebo Comparator group

Description:

placebo 2 pills/day for 3 months

Treatment:

Dietary Supplement: Sineos