A Novel Equation for Estimating Sodium Intake in Peritoneal Dialysis.

Peking University

Status: Not yet enrolling

Conditions: Dietary Sodium Intake

Study type: Observational

Funder types: Other

Identifiers

NCT05955417

2022SF38

Details and patient eligibility

About

This study aims to develop a novel equation for estimating sodium intake in anuric peritoneal dialysis patients, and then to validate its precision and accuracy.

Full description

Dietary sodium intake is closely associated with the prognosis of chronic kidney disease (CKD) patients. Previous studies have developed an equation for estimating dietary sodium intake through 24-hour urine sodium in CKD, which are not applicable in peritoneal dialysis patients. This study aims to develop a novel equation for estimating dietary sodium intake in 20 anuric peritoneal dialysis patients, using accurately measured dietary sodium as the dependent variable and peritoneal sodium clearance and its related variables as independent variables, and then to validate the precision and accuracy of the novel equation in another 20 anuric peritoneal dialysis patients.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Peritoneal dialysis vintage >3 months.
• 18-80 years old.
• No residual renal function (urine volume<200ml/day).
• Continuous ambulatory peritoneal dialysis or manual intermittent peritoneal dialysis.

Exclusion criteria

• Peritonitis in the past month.
• Acute systemic infection, cardio-cerebrovascular complications and surgical trauma in the past month.
• Uncorrected hyponatremia (blood sodium<130mmol/L).
• Prescribed with sodium bicarbonate and other drugs containing sodium.
• Prescribed with glucocorticoids and aldosterone antagonists.
• Dysfunction of peritoneal dialysis catheter.
• Malignant tumor receiving radiotherapy and chemotherapy, severe dyspepsia or eating disorder.
• Body fluid loss due to vomit, diarrhea, massive sweating, or other causes.
• Cannot follow the research scheme.
• Refuse to participate in this study.