A nUtrition and Lifestyle Intervention in Patients With Pulmonary Arterial HypertensIon (UPHILL)

Amsterdam UMC, location VUmc

Status: Completed

Conditions: Pulmonary Arterial Hypertension

Treatments: Dietary Supplement: Diet; Behavioral: E-learning

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05318950

NL66484.029.18

Details and patient eligibility

About

Rationale: Nutrition and lifestyle interventions are currently not implemented in usual clinical care of PAH-patients. Mainly because there is little known on the relation between pathology, nutrition and lifestyle. Patients who suffer from Pulmonary Arterial Hypertension feel insecure about their nutrition and lifestyle. The investigators hypothesize that an intervention on nutrition and lifestyle can improve the patients' quality of life.

Objective: To explore the effect of a nutrition and lifestyle intervention on quality of life for patients suffering from PAH.

Study design: Investigator initiated intervention study with control group. Study population: investigators aim to include 70 patients (18 - 80 years) with idiopathic, hereditable or drug related PAH, who have been stable for at least three months and are self-sufficient and/or have a family who's willing to participate in the lifestyle changes.

Intervention (if applicable): Nutritional status, - education, - intervention and - compliance.

Main study parameters/endpoints: This is an intervention study in which the investigators will asses the effect of a nutrition and lifestyle intervention on quality of life measured by SF-36 overall outcome with a significant difference of 6.35.

Nature and extent of the burden and risks associated with participation, benefit and group relatedness: The burden for the patient exists of 12 extra visits to the hospital and contact moments, over a period of 11 months, as well compliance to the diet and lifestyle. There is minimal risk in participation.

Full description

Baseline nutritional assessment

Nutritional education:

8 online lessons containing information about nutrition, lifestyle and general health with complementary tips regarding PH. All participants recieve workbook with assignments.

Nutritional intervention:

Group A: MedDASH diet (55% carbohydrates, 25% amino acids, 20% fatty acids) Group B: MedDASHfat diet (10% carbohydrates, 25% amino acids, 65% fatty acids) Control group: no diet.

Follow-up:

Patients in intervention arm followed for a period of 6 months to assess compliance.

Enrollment: 40 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of idiopathic PAH, hereditable PAH or drug related PAH
• Age between 18 and 80
• NYHA II or III and stable for at least 3 months, determined by a stable 6minute walk test with a difference of <10%.
• Self-sufficient and/or compliance from partner and/or family
• Creatinine > 30 ml/min
• Able to understand and willing to sign the Informed Consent Form

Exclusion criteria

• • Pregnant subjects
• Fat percentage < 10% > 50 %
• One or more of the following comorbidities: diabetes mellitus type one or two, clinically relevant thyroid disease
• Known history of noncompliance considering therapies

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Single Blind

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40 participants in 4 patient groups

Control

No Intervention group

Description:

No intervention

E-learning

Experimental group

Description:

E-learning: 8 lessons about nutrition and lifestyle

Treatment:

Behavioral: E-learning

Diet A

Experimental group

Description:

MedDASH diet (55% carbohydrates, 25% amino acids, 20% fatty acids)

Treatment:

Behavioral: E-learning

Dietary Supplement: Diet

Diet B

Experimental group

Description:

MedDASHfat diet (10% carbohydrates, 25% amino acids, 65% fatty acids)

Treatment:

Behavioral: E-learning

Dietary Supplement: Diet