A Nutritional Approach to Minimal Hepatic Encephalopathy

Tel Aviv Sourasky Medical Center

Status

Unknown

Conditions

Minimal Hepatic Encephalopathy

Treatments

Other: Nutritional Intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT01083446

0236-08-TLV

TASMC-08-NV-236

Details and patient eligibility

About

This trial will study a possible effect of standard Israeli breakfast (30% of caloric value and 21 gram protein) on cognitive and executive functions (working memory, visual memory, concentration and coordination), on patients with mild-moderate liver cirrhosis.

Enrollment

60 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All consented adults (age > 18), with the diagnosis of CHILD A cirrhosis with MELD score of < 10.
Diagnosis of liver cirrhosis as documented by liver biopsy (stage IV) and / or fibroscan (score > 12 kpa) and / or fibrotest (score > 0.74) and /or imaging.

Exclusion criteria

History of > grade II hepatic encephalopathy (HE).
Diagnosis of dementia, Parkinson disease, Schizophrenia (Patients with major depression will be noted but not excluded).
Use of sedatives, tranquilizers or anti- psychotic medication during and/or 2 weeks prior to enrolling Use of antibiotics for any length of period during and/or 2 weeks prior to enrolling.
Current use of lactulose or neomycin.
Use of alcohol or elicit drugs during and/ or 6 months prior to enrolling.