A One Health Study of Monkeypox Human Infection (AFRIPOX)

Pasteur Institute

Status: Active, not recruiting

Conditions: Monkeypox Virus Infection

Treatments: Other: Scabs and pus samples; Other: blood samples

Study type: Observational

Funder types: Industry

Identifiers

NCT05058898

2019-047

Details and patient eligibility

About

This multidisciplinary project aim to understand the epidemiology of the monkeypox in Central African Republic through the identification of the animal reservoir, the clinical and epidemiological description of the human outbreak, through an ethnological approach around risk factors of the disease and through an ecological approach of the ecological context of emergence, and the improvement of biological diagnosis.

Full description

This project is composed by monkyepox disease outbreak investigation in the CAR following national surveillance framework.

Enrollment: 280 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Human population in villages affected by monkeypox epidemics: patients who developed monkeypox and their contacts
• Health care personnel (paramedics, nurses, doctors) who work or have worked in affected villages
• Traditional healers, diviners
• Members of villages affected by past monkeypox epidemics

Exclusion criteria

• area not accessible to investigation
• refusal to participate
• inability to obtain consent

Trial design

280 participants in 4 patient groups

Risk factors transmission cases

Description:

Human cases of monkeypox confirmed by PCR

Treatment:

Other: Scabs and pus samples

Other: blood samples

Risk factors transmission contacts and co-exposures

Description:

Human contact of confirmed monkeypox cases

Treatment:

Other: blood samples

Serological follow up cases

Description:

Human cases of monkeypox confirmed by PCR from Lobaye region

Treatment:

Other: Scabs and pus samples

Other: blood samples

Serological follow up contacts and co-exposures

Description:

Human contact of confirmed monkeypox cases from Lobaye region adjusted for age, month of the year and village of origin

Treatment:

Other: blood samples