A Pharmacokinetic and Pharmacogenetic Study in Patients Receiving Sulfamethoxazole-trimethoprim Therapy

National Taiwan University

Status: Unknown

Conditions: Pneumocystis Jirovecii Pneumonia

Study type: Observational

Funder types: Other

Identifiers

NCT02045160

201312090RINC

Details and patient eligibility

About

In this study, we aim to investigate the incidence of the adverse reactions, the effectiveness and the gene polymorphism associated with the plasma level of sulfamethoxazole-trimethoprim and their metabolites (including N4-acetyl-sulfamethoxazole, sulfamethoxazole hydroxylamine and sulfamethoxazole-nitroso). And we also aim to investigate the factors associated with the sulfamethoxazole-trimethoprim induced acute psychosis.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• males and females aged 20 years or older
• using oral or intravenous form of sulfamethoxazole-trimethoprim

Exclusion criteria

• patients who are under 20 years of age

Trial design

1,000 participants in 1 patient group

Sulfamethoxazole-trimethoprim treatment