A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors (DPT02)

AstraZeneca

Status and phase: Enrolling; Phase 2

Conditions: Part 2: HER2 Expressing/Amplified Solid Tumors Excluding Breast, Gastric, Colorectal Cancer; Part 1: Bladder, Biliary Tract, Cervical, Endometrial, Ovarian, Pancreatic Cancer, Rare Tumors, Any Tumor Type Excluding Breast, Gastric, Colorectal Cancer

Treatments: Drug: Trastuzumab deruxtecan

Study type: Interventional

Funder types: Industry

Identifiers

NCT04482309

2020-001574-29 (EudraCT Number)

D967VC00001

Details and patient eligibility

About

This is an open-label, multi-center, multi-cohort, Phase 2 study to evaluate the efficacy and safety of trastuzumab deruxtecan (T-DXd) for the treatment of selected HER2-expressing tumors.

This study will consist of Part 1 which includes 7 cohorts of: urothelial bladder cancer, biliary tract cancer, cervical cancer, endometrial cancer, ovarian cancer, pancreatic cancer, and rare tumors; and Part 2 which includes 5 cohorts A to E of: A) any tumor type that is HER2 IHC 3+ (excluding breast, gastric cancer, and colorectal cancer), B) any tumor type that is HER2 IHC 2+/ISH+ (excluding breast, gastric cancer, and colorectal cancer), C) HER2 IHC 2+ or 1+ endometrial cancer, D) HER2 IHC 2+ or 1+ ovarian cancer, and E) HER2 IHC 2+ or 1+ cervical cancer.

Study hypothesis: Trastuzumab deruxtecan will show meaningful clinical activity and a favorable risk benefit profile in selected HER2-expressing solid tumors.

Enrollment: 468 estimated patients

Sex: All

Ages: 18 to 120 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Locally advanced, unresectable, or metastatic disease based on most recent imaging.

• Part 1:The respective cohorts for patient inclusion are:

  • Cohort 1: Biliary tract cancer
  • Cohort 2: Bladder cancer
  • Cohort 3: Cervical cancer
  • Cohort 4: Endometrial cancer
  • Cohort 5: Epithelial ovarian cancer
  • Cohort 6: Pancreatic cancer
  • Cohort 7: Rare tumors: This cohort will consist of patients with tumors that express HER2, excluding the tumors mentioned above, and breast, non-small cell lung cancer, gastric cancer, and colorectal cancer.

• Part 2:The respective cohorts for patient inclusion are:

  • Cohort A: Metastatic or advanced solid tumors that are HER2 IHC 3+ (excluding breast, gastric cancer, and colorectal cancer). Patients with non-small cell lung cancer can be included.
  • Cohort B: Metastatic or advanced solid tumors that are HER2 IHC 2+/ISH+ any tumor type (excluding breast, gastric cancer, and colorectal cancer). Patients with non-small cell lung cancer can be included.
  • Cohort C: Metastatic or advanced solid endometrial cancer that is HER2 IHC 2+ or 1+.
  • Cohort D: Metastatic or advanced ovarian cancer that is HER2 IHC 2+ or 1+.
  • Cohort E: Metastatic or advanced solid cervical cancer that is HER2 IHC 2+ or 1+.

• Progressed following prior treatment or who have no satisfactory alternative treatment option.

• Prior HER2 targeting therapy is permitted.

• HER2 expression scored using current ASCO/CAP guidelines for scoring HER2 for gastric cancer.

  • Part 1: IHC 3+ or IHC 2+ by local or central assessment
  • Part 2: IHC and ISH results by central assessment as pre-defined for each cohort

• Has measurable target disease assessed by the Investigator based on RECIST version 1.1.

• Has protocol- defined adequate organ function including cardiac, renal and hepatic function.

Exclusion criteria

• History of non-infectious pneumonitis/ILD that required steroids, current ILD, or where suspected ILD that cannot be ruled out by imaging at screening
• Lung-specific intercurrent clinically significant severe illnesses
• Uncontrolled infection requiring intravenous (IV) antibiotics, antivirals, or antifungals
• Pleural effusion, ascites or pericardial effusion that requires drainage, peritoneal shunt, or Cell-free and Concentrated Ascites Reinfusion Therapy (CART
• Known Somatic DNA mutation of HER2 (ERBB2) without tumoral HER2 protein expression.
• Primary diagnosis of adenocarcinoma of the breast, adenocarcinoma of the colon or rectum, adenocarcinoma of the gastric body or gastro-esophageal junction, or non-small cell lung cancer for Part 1. For Part 2, patients with primary diagnosis of adenocarcinoma of the breast, adenocarcinoma of the colon or rectum, adenocarcinoma of the gastric body or gastro-esophageal junction will be excluded.
• Medical conditions that may interfere with the subject's participation in the study.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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468 participants in 12 patient groups

Part 1 Cohort 1

Experimental group

Description:

Biliary tract cancer

Treatment:

Drug: Trastuzumab deruxtecan

Part 1 Cohort 2

Experimental group

Description:

Bladder cancer

Treatment:

Drug: Trastuzumab deruxtecan

Part 1 Cohort 3

Experimental group

Description:

Cervical cancer

Treatment:

Drug: Trastuzumab deruxtecan

Part 1 Cohort 4

Experimental group

Description:

Endometrial cancer

Treatment:

Drug: Trastuzumab deruxtecan

Part 1 Cohort 5

Experimental group

Description:

Ovarian cancer

Treatment:

Drug: Trastuzumab deruxtecan

Part 1 Cohort 6

Experimental group

Description:

Pancreatic cancer

Treatment:

Drug: Trastuzumab deruxtecan

Part 1 Cohort 7

Experimental group

Description:

Rare tumors

Treatment:

Drug: Trastuzumab deruxtecan

Part 2 Cohort A

Experimental group

Description:

Any tumor type that is HER2 IHC 3+ (excluding breast, gastric cancer, and colorectal cancer)

Treatment:

Drug: Trastuzumab deruxtecan

Part 2 Cohort B

Experimental group

Description:

Any tumor type that is HER2 IHC 2+/ISH+ (excluding breast, gastric cancer, and colorectal cancer)

Treatment:

Drug: Trastuzumab deruxtecan

Part 2 Cohort C

Experimental group

Description:

HER2 IHC 2+ or 1+ endometrial cancer

Treatment:

Drug: Trastuzumab deruxtecan

Part 2 Cohort D

Experimental group

Description:

HER2 IHC 2+ or 1+ ovarian cancer

Treatment:

Drug: Trastuzumab deruxtecan

Part 2 Cohort E

Experimental group

Description:

HER2 IHC 2+ or 1+ cervical cancer

Treatment:

Drug: Trastuzumab deruxtecan