Status and phase
Conditions
Treatments
Study type
Funder types
Identifiers
About
To learn if giving cemiplimab and cetuximab before salvage surgery can help to control recurrent oral cavity squamous cell carcinoma.
Full description
Primary Objective:
Secondary Objective:
Tertiary/Exploratory Objective:
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Participants ≥18 years with histology-proven recurrent oral cavity squamous cell carcinoma.
Amenable to salvage surgery
Disease recurrence at least 3 months after completion of curative-intent therapy (including surgery, post operatory radiation, and/or chemotherapy)
Measurable disease per RECIST 1.1
Performance status ECOG of 0 or 1
Willing to undergo baseline (if archival tumor specimen is not available) and on-treatment biopsy for correlative studies
Laboratory measurements, blood counts:
Laboratory measurements, renal function:
a) Creatinine clearance ≥ 30 mL/min as assessed by the Cockcroft-Gault equation
Laboratory measurements, hepatic function:
Female participants with reproductive potential must practice two effective contraceptive measures for the duration of study drug therapy and for at least 90 days after completion of study therapy. The two birth control methods can be either two barrier methods or a barrier method plus a hormonal method to prevent pregnancy. The following are considered adequate barrier methods of contraception: diaphragm, condom, copper intrauterine device, sponge, or spermicide. Appropriate hormonal contraceptives will include any registered and marketed contraceptive agent that contains an estrogen and/or a progestational agent (including oral, subcutaneous, intrauterine, or intramuscular agents).
Male participants who are sexually active with women with reproductive potential must agree to use contraception for the duration of treatment and for at least 90 days after completion of study therapy.
Exclusion criteria
Disease recurrence within 3 months after completion of definitive treatment (including surgery, post operatory, systemic therapy)
Distant metastatic disease (M1), visceral and/or distant nodal
Any prior treatment with an anti-PD1/PD-L1 agent
Participants with a condition requiring corticosteroid therapy (>10 mg prednisone/day or equivalent) within 14 days of the first dose of study drug.
Exceptions: Physiologic replacement doses are allowed even if they are >10 mg of prednisone/day or equivalent, as long as they are not being administered for immunosuppressive intent. Inhaled or topical steroids are permitted, provided that they are not for treatment of an autoimmune disorder.
Participants with active, known, or suspected autoimmune disease that has required systemic therapy within 5 years of the projected enrollment date.
Exceptions: Participants with vitiligo, type I diabetes mellitus, and endocrinopathies (including hypothyroidism due to autoimmune thyroiditis) only requiring hormone replacement, childhood asthma that has resolved, or psoriasis that does not require systemic treatment are permitted.
History of interstitial lung disease (eg, idiopathic pulmonary fibrosis, organizing pneumonia) or active, noninfectious pneumonitis that required immune-suppressive doses of glucocorticoids to assist with management.
Recipient of a solid organ transplant (other than corneal transplants)
Prior allogeneic stem cell transplantation, or autologous stem cell transplantation
History of previous malignancy other than malignancy treated with curative intent within less than 5 years. Participants with the following diagnoses represents an exception and may enroll if ≥ 1 year with no evidence of active disease before the first dose of the study drug:
Evidence of uncontrolled, active infection, requiring systemic anti-bacterial, anti-viral or anti-fungal therapy ≤ 10 days prior to administration of cemiplimab and cetuximab. Subjects with known hepatitis B, hepatitis C (HCV), or HIV infection could go on study if the viral load is undetectable at screening.
Disease or medical conditions that would substantially increase the risk-benefit ratio of participating in the study that include acute myocardial infarction within the last 6 months, unstable angina, uncontrolled diabetes mellitus, significant active infections, and congestive heart failure New York Heart Association Class III-IV
Female participants who are pregnant or breast-feeding
Known hypersensitivity to any of the study drugs, the metabolites, or formulation excipient
Primary purpose
Allocation
Interventional model
Masking
17 participants in 1 patient group
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Central trial contact
Luana Guimaraes De Sousa, MD
Data sourced from clinicaltrials.gov
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