A Phase I Dose-Escalation Study of IMGN388 in Patients With Solid Tumors

ImmunoGen

Status and phase

Completed

Phase 1

Conditions

Solid Tumor

Treatments

Drug: IMGN388

Study type

Interventional

Funder types

Industry

Identifiers

NCT00721669

IMGN388

Details and patient eligibility

About

Primary objective is to evaluate the safety and PK of IMGN388

Full description

The secondary objectives are to assess the pharmacodynamics, immunogenicity, and tumor response of IMGN388 administered as an IV infusion once every three weeks in patients with solid tumors

Enrollment

60 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male or female age greater than 18 years
Signed informed consent(s): Patients must provide informed consent for study participation prior to performing any study-specific procedures
Histologically confirmed solid tumor that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective
Specifically for the dose expansion phase, enrollment will be limited to patients with αv integrin positive melanomas or carcinomas of breast, lung, or ovary. Patients must also have confirmation of αv integrin expression performed prior to enrollment by immunohistochemical assessment for αv integrin on archived or if not available, freshly collected tumor biopsy samples. αv integrin positive tumors are defined as having a staining intensity of at least 2+ and a staining uniformity of heterogeneous (25 - 75% of tumor cells stain positively for αv integrin) or homogeneous staining (>75% of tumor cells are positive for αv integrin) of tumor cells when evaluated by immunohistochemistry .
Evidence of measurable or evaluable metastatic disease at baseline
Eastern Cooperative Oncology Group (ECOG) Performance Status score of less than or equal to 2
Adequate bone marrow, liver, and renal function at the time of first dose of study agent, as described below:
Hemoglobin greater than or equal to 9.0 g/dL (5.6 mmol/L; 90 g/L) without transfusion dependency
Absolute neutrophil count (ANC)greater than or equal to 1.5 x 109/L (1500/mm3) without hematopoietic cytokine support
Platelets greater than or equal to 100,000 x 109/L (100,000/mm3) without transfusion dependency
Coagulation [prothrombin time (PT) or international normalized ratio (INR) and activated partial prothrombin time (aPTT)] ≤ 1.25 x upper limit of normal (ULN)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 x ULN if no liver metastasis; ≤ 5 x ULN if liver metastasis
Total Bilirubin ≤ 1.5 x ULN
Serum creatinine ≤ 1.5 x ULN
Female patients must be postmenopausal (at least 12 months since last menses), surgically sterile, abstinent, or, if sexually active, be practicing an effective method of birth control (e.g., prescription oral contraceptives, contraceptive injections, intrauterine device, double-barrier method, contraceptive patch, male partner sterilization) before study entry, for the duration of study participation, and for three months after the last infusion of study agent and must have a negative urine or serum pregnancy test within 1 week before beginning treatment on this study and at all specified timepoints throughout the study. Men must be sterilized or agree to use a double-barrier method of birth control and must agree to not donate sperm during the study and for three months after the last infusion of study agent.
Able to adhere to study visit schedule and all protocol requirements
The anticipated life expectancy is such that the patient is expected to be able to participate for the duration of the study

Exclusion criteria

Patients meeting any of the following criteria may not be enrolled in the study:

Residual toxicities resulting from previous therapy that are ≥ Grade 1
Neuropathy of > Grade 1
History of uveitis within 6 months of first dose of study agent or presenting with uveitis at baseline
Concomitant or prior malignancy (other than the one under study) except adequately treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix
Patients with solid tumors with history of active bleeding
Treatment with systemic cancer therapy, radiotherapy or any investigational agent within 4 weeks or five half-lives (whichever is longer) of first dose of study agent
Known allergies or clinically important reactions to human proteins or to therapeutic antibodies
Major surgery within 4 weeks of first dose of study agent, or planning to have surgery (except for minor surgical procedures) during the study, or planned major surgery within 8 weeks after the last dose of study agent
Serious concurrent illness (medical or psychiatric), altered mental status (e.g., dementia) or any uncontrolled medical condition (eg, uncontrolled diabetes), including the presence of laboratory abnormalities, that would place the patient at unacceptable risk by participating in the study or would confound the ability to interpret data from the study
Uncontrolled infection, clinically important active infection within 4 weeks before the first dose of study agent, or currently receiving treatment for an infection
Active angina pectoris or New York Heart Association (NYHA) Class III or IV heart disease. Cardiac disease characterized by significant ischemic coronary disease, significant arrhythmias, or congestive heart failure (greater than NYHA Class II) or myocardial infraction within the past 6 months
Known or symptomatic central nervous system (CNS) metastases
Known to be seropositive for human immunodeficiency virus (HIV), or active Hepatitis A, B, or C infection
Any other concomitant anti-cancer treatment such as immunotherapy, biotherapy, radiotherapy, chemotherapy, investigative therapy, or high-dose steroids; however, low-dose steroids and Luteinizing Hormone Releasing Hormone (LHRH) at doses that have been stable for ≥ 14 days are permitted for patients with prostate cancer
Any medical condition that, in the opinion of the investigator, may compromise the safety of the patient or their ability to receive study treatment
Pregnant or lactating women