A Phase I Study of iPS Cell Generation From Patients With COPD

Mayo Clinic

Status: Completed

Conditions: Lung Diseases, Obstructive; Cancer of the Lung; Cancer of Lung; Pulmonary Cancer; Pulmonary Neoplasms; Lung Cancer; Carcinoma, Small Cell; Neoplasms, Pulmonary; Pulmonary Emphysema; Neoplasms, Lung; Respiratory Tract Diseases; Carcinoma, Non-Small-Cell Lung; Thoracic Diseases; COPD

Treatments: Other: Skin Biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT01860898

09-005334

Details and patient eligibility

About

As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, the investigators will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells.

Enrollment: 31 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Undergoing Thoracic Surgery at the Mayo Clinic Rochester
• Presence of a Thoracic Disease

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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31 participants in 1 patient group

Skin Biopsy

Other group

Treatment:

Other: Skin Biopsy