A Phase II Study of Parotid-gland Sparing IMRT in Patients With Midline Tumour of the Head and Neck (PARSPORT-II)

Royal Marsden NHS Foundation Trust

Status: Completed

Conditions: Oropharyngeal Squamous Cell Cancer; Hypopharyngeal Squamous Cell Cancer

Treatments: Radiation: Intensity modulated radiotherapy

Study type: Observational

Funder types: Other

Identifiers

NCT02149602

CCR 2588

Details and patient eligibility

About

This study is a phase II trial designed to test the feasibility of delivering IMRT to head and neck cancer patients with tumours arising in the midline (oropharynx and hypopharynx), and to assess possible improvement in reducing the incidence of xerostomia with bilateral superficial lobe parotid sparing IMRT.

Enrollment: 120 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• histologically confirmed locally advanced HNSCC arising from the oropharynx or hypopharynx with high risk of bilateral parapharyngeal space involvement

Exclusion criteria

• Patients <18 years old or with a previous malignancy other than non-melanomatous skin cancer

Trial design

120 participants in 1 patient group

oropharyngeal and hypopharyngeal HNSCC

Description:

Intensity Modulated Radiotherapy HPV positive and HPV negative

Treatment:

Radiation: Intensity modulated radiotherapy