A Phase II Study of Rituximab Combined With CHOP in T-cell Angio-immunoblastic Lymphoma

Lymphoma Study Association (LYSA)

Status and phase

Completed

Phase 2

Conditions

Untreated T-cell Angioimmunoblastic Lymphoma

Treatments

Drug: Vincristine

Drug: Doxorubicine

Drug: Rituximab

Drug: Prednisone

Drug: Cyclophosphamide

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00169156

RAIL

2005-002602-37 (EudraCT Number)

Details and patient eligibility

About

To evaluate the efficacy and the safety of a front-line treatment combining CHOP regimen and rituximab in patients aged 60 to 80 years with previously untreated AIL.

Full description

This is a multicentric, open-label, non-randomized clinical study, evaluating the efficacy and the safety of a front-line treatment combining CHOP regimen and rituximab in patients aged 60 to 80 years with previously untreated AIL.

It is anticipated that 25 subjects will be enrolled over 2 years (from 2005 / 2007).Analysis performed every 5 patients (based on triangular test).

The duration of the treatment period is approximately 25 weeks and patients are followed until Death.

The total Duration of the study is expected to be 2.5 years.

Enrollment

27 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with histologically proven T-cell angioimmunoblastic lymphoma (AIL) on lymph node biopsy.
Aged from 60 to 80 years.
Patient not previously treated (except corticosteroids providing they have been initiated less than 10 days before inclusion).
ECOG performance status 0 to 2.
With a minimum of life expectancy > 3 months.
Negative HIV, HBV and HCV serological tests < 4 weeks (except after vaccination).
Having previously signed a written informed consent.

Exclusion criteria

Any other histological type of T-cell lymphoma.
Central nervous system or meningeal involvement by lymphoma.
Contra-indication to any drug included in the R-CHOP regimen.
Concurrent severe disease (according to the investigator's decision).
Active bacterial, viral or fungal infection.
Poor renal function (serum creatinine level > 150 µmol/L) or impaired liver function tests (total bilirubin level > 30 µmol/L, transaminases > 2.5 upper normal limits) unless they are related to the lymphoma.
Poor bone marrow reserve as defined by neutrophils < 1.5 x 109/L or platelets < 100 x 109/L, unless related to bone marrow infiltration.
Any history of cancer during the last 5 years, with the exception of non basal cell carcinoma of the skin or in situ carcinoma of the cervix.
Treatment with any investigational drug within 30 days before planned first cycle of chemotherapy and during the study.
Patient under tutelage.