A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH)

Sciwind Biosciences

Status and phase: Enrolling; Phase 2

Conditions: Obesity; Weight Management

Treatments: Drug: XW003 injection; Drug: semaglutide injection

Study type: Interventional

Funder types: Industry

Identifiers

NCT07073417

SCW0502-1122

Details and patient eligibility

About

The aim of the study is to compare the efficacy and safety of XW003 injection versus semaglutide injection in Chinese adults with obesity

Full description

In this Phase II study, eligible participants will be randomized into one of the two cohorts in a 1:1 ratio to receive once-weekly subcutaneous XW003 injection or semaglutide injection, including a dose-escalation period, a core treatment period and a treatment extension period, for up to 60 weeks.

Enrollment: 160 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI≥30 kg/m2 at screening, waist circumference ≥90 cm for men and ≥85 cm for women.
• Weight change of less than 5% within 3 months prior to screening (self-reported).

Exclusion criteria

• Diagnosis of obesity due to endocrine disorders or a single gene mutation, including but not limited to hypothalamic obesity, pituitary obesity, Cushing's syndrome, hypothyroidic obesity (except for those with normal thyroid function at screening and expected to remain unchanged throughout the trial period after at least 3 months of thyroid hormone replacement therapy), insulinoma, acromegaly.
• History of bariatric surgery or planning to undergo bariatric surgery or use other weight-loss drugs or devices during the trial (except acupuncture for weight loss, liposuction, or abdominal fat removal for more than one year before screening; Except the removal or expulsion of the airbag in the stomach for more than 1 year before screening.
• Diagnosis with any type of diabetes (except gestational diabetes).
• Have used any weight-loss drugs, hypoglycemic drugs, or drugs that may cause significant weight gain within 3 months prior to screening.
• History of acute or chronic pancreatitis or pancreatic injury, history of symptomatic gallbladder disease (except cholecystectomy).
• History of clinically significant gastric emptying abnormalities, such as gastroparesis or gastric outlet obstruction.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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160 participants in 2 patient groups

XW003

Experimental group

Description:

once weekly

Treatment:

Drug: XW003 injection

semaglutide

Active Comparator group

Description:

once weekly

Treatment:

Drug: semaglutide injection