A Phase II Trial OF Carboplatin, ABI-007 (Abraxane) And Sorafenib (BAY 43-9006) in Metastatic Melanoma

Mt. Sinai Medical Center, Miami

Status and phase

Completed

Phase 2

Conditions

Malignant Melanoma

Treatments

Drug: ABI-007(Abraxane)

Drug: Sorafenib (BAY 43-9006)

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00483301

MEL0205

Details and patient eligibility

About

The purpose of this study is to compare the effects, good and/or bad, of Carboplatin and ABI-007 (Abraxane) in combination with Sorafenib (BAY 43-9006) on Melanoma.

Full description

The primary objective of this phase II multicenter trial is to:

Measure the response rate (RR) of this combination and schedule in patients with metastatic melanoma

The secondary objectives are to:

Assess the safety and toxicity of this regimen in this patient population

Determine the 1-year and median PFS of patients treated according to protocol

Determine overall survival (OS)

STUDY DESIGN

This will be a Phase II study single arm study with a two-stage design with a maximum sample size of 43 patients, 18 in the first stage and 25 in the second stage.

Study duration: A minimum yearly accrual of 10-15 patients/institution is expected. Therefore, to reach the first stage, the study will take 1.2 to 1.8 years with one institution, 0.6 to 0.9 years with 2 institutions, and 0.4 to 0.6 years with 3. If the study continues to full accrual to 43 patients, completion will take 2.9 to 4.3 years with one institution, 1.4 to 2.2 years with two and 0.96 to 1.43 years with three institutions.

Enrollment

34 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Histologically confirmed diagnosis of melanoma with measurable disease
Patients with stage IV, previously untreated, refractory to initial therapy or progressing after response to initial therapy
Patients with unresectable stage III, including unresectable in-transit metastases
Two prior chemotherapy regimen is allowed
One prior immunotherapy regimen is allowed
No other concurrent investigational therapy
Radiation therapy to non-target lesions or to one of multiple target lesions may be allowed on a case-by-case basis
Patients must be past the nadir from previous cytotoxic therapy
Age at least 18 years
ECOG performance status 0-2
Hemoglobin > 9.0 g/dl, absolute neutrophil count (ANC) > 1,500/mm3, platelet count > 100,000/mm3
Total bilirubin within normal limits, ALT and AST < 2.0 x the ULN ( < 5 x ULN for patients with liver involvement), INR < 1.5 and aPTT within normal limits. Patients who receive anti-coagulation treatment with an agent such as warfarin or heparin may be allowed to participate. For patients on warfarin, close monitoring of at least weekly evaluations will be performed until INR is stable based on a measurement at pre dose, as defined by the local standard of care.
Creatinine < 1.5 x ULN, serum calcium within normal limits
Patients with stable brain metastasis who have been treated with either whole brain radiation or Gamma Knife and have been off steroids for > 4 weeks
Women of childbearing potential and men must agree to use adequate contraception (barrier method of birth control) prior to study entry and for the duration of study participation. Men and women should use adequate birth control for at least three months after the last administration of protocol drugs. Women of childbearing potential must have a negative serum pregnancy test performed within 7 days prior to the start of treatment.
Ability to understand and sign a written informed consent document. All patients must have a signed informed consent before registration and initiation of therapy

Exclusion criteria

Cardiac disease: Congestive heart failure > class II NYHA.
Patients must not have unstable angina (anginal symptoms at rest) or new onset angina (began within the last 3 months) or myocardial infarction within the past 6 months.
Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy.
Uncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg, despite optimal medical management.
No known severe hypersensitivity or suspected allergy to sorafenib, ABI-007 or any of the excipients
Patients with neurological symptoms must undergo a CT scan/MRI of the brain to exclude progressing brain metastasis.
Peripheral neuropathy greater than grade II
Serious intercurrent medical or psychiatric illness, including serious active infection
Known human immunodeficiency virus (HIV) infection or chronic Hepatitis B or C.
Thrombotic or embolic events such as a cerebrovascular accident including transient ischemic attacks within the past 6 months.
Pulmonary hemorrhage/bleeding event > CTCAE Grade 2 within 4 weeks of first dose of study drug.
Any other hemorrhage/bleeding event > CTCAE Grade 3 within 4 weeks of first dose of study drug.
Serious non-healing wound, ulcer, or bone fracture.
Evidence or history of bleeding diathesis or coagulopathy
Major surgery, open biopsy or significant traumatic injury within 4 weeks of first study drug.
Use of St. John's Wort or rifampin (rifampicin)
Any condition that impairs patient's ability to swallow whole pills.
Any malabsorption problem
No treatment for melanoma within the previous 4 weeks.