A Phase III Randomized, Double Blind, Placebo Controlled Multi-center Study of Panobinostat for Maintenance of Response in Patients With Hodgkin's Lymphoma (HL) (PATH)

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Novartis

Status and phase

Completed
Phase 3

Conditions

Hodgkin's Lymphoma

Treatments

Drug: Placebo
Drug: Panobinostat

Study type

Interventional

Funder types

Industry

Identifiers

NCT01034163
2009-014846-26
CLBH589E2301

Details and patient eligibility

About

The primary objective was to provide drug to ongoing patients who were receiving panobinostat and to characterize the safety and tolerability of panobinostat in patients with HL after achieving a complete response following autologous hematopoietic stem cell transplant (AHSCT) with high dose chemotherapy (HDT). Primary objective as stated above reflects a change from the original protocol as of an amendment. The original objective was no longer feasible with only 41 of 367 patients randomized after the study was halted due to poor recruitment. An amendment was written to allow patients on panobinostat to continue their treatment until discontinuation/completion criteria were met (patients were unblinded). Therefore, the study was completed as per this amendment. No secondary objectives were included for this trial from the amendment; this was a change from the original protocol.

Enrollment

41 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patient age is greater than or equal to 18 years
  • Patient has a history of histologically confirmed classical HL (i.e. Nodular sclerosing (NSHL), Mixed-cellularity (MCHL), Lymphocyte-rich (LRHL), Lymphocyte depleted (LDHL))

Patient has achieved a complete response by CT/MRI scan within 9 weeks (± 1 week) from the day of their first autologous peripheral blood/ bone marrow stem cell transfusion (AHSCT) following HDT. Complete response is defined as:

Normalization of all nodes and lesions compared to pre-transplant scan performed prior to salvage therapy for relapse. Any residual abnormal masses on the post transplant CT/MRI must be metabolically inactive on a PET scan.

Patient has at least one of the following factors that places them at risk for relapse:

  • Primary refractory disease (including relapse in ≤ 3 months of completion of 1st line treatment)
  • First relapse >3 but <12 months from last dose of 1st line treatment
  • Multiple relapses (prior to transplant)
  • Stage III/IV disease (at relapse, prior to transplant)
  • Hemoglobin <10.5 gm/dL (at relapse, prior to transplant)

Exclusion criteria

Patient has been treated with allogeneic transplant 2. Patient has received any anti-lymphoma therapy after AHSCT including but not limited to:

  • chemotherapy prior to start of study
  • biologic immunotherapy including monoclonal antibodies or experimental therapy prior to start of study
  • radiation therapy 3. Patient has not recovered from reversible toxicity due to any prior therapies (e.g. returned to baseline or Grade ≤1) except for hematological laboratory parameters Note: Patient does not meet this criteria if the toxicity is stable and irreversible, and there is no evidence that panobinostat causes a similar toxicity 4. Patient has received prior treatment with DAC inhibitors including panobinostat

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

41 participants in 2 patient groups, including a placebo group

Panobinostat (PAN)
Experimental group
Description:
Participants received 45 mg orally 3 times a week (TIW), every other week (QOW),
Treatment:
Drug: Panobinostat
Placebo
Placebo Comparator group
Description:
Participants received matching placebo to PAN TIW, QOW.
Treatment:
Drug: Placebo

Trial contacts and locations

35

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Data sourced from clinicaltrials.gov

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