A Photodynamic Therapy for Treatment of Actinic Keratoses

Northwestern University

Status

Completed

Conditions

Actinic Keratoses

Treatments

Procedure: Photodynamic therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT00558688

STU00000312

Details and patient eligibility

About

The purpose of this study is to compare the efficacy of photodynamic therapy with 5-aminolevulinic acid and intense pulsed light vs absence of treatment for actinic keratoses.

Full description

This study seeks to evaluate the efficacy of photodynamic therapy with 5-aminolevulinic acid and intense pulsed light vs. absence of treatment for actinic keratoses

Enrollment

20 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age greater than or equal to 18 years

Have a t least 4 nonhypertrophic AK lesions on the body
The subjects are in good health
The subject has the willingness and the ability to understand and provide informed consent for the use of their tissue and communicate to the investigator

Exclusion criteria

Subjects who are pregnant or lactating
Subjects with a history of cutaneous photosensitivity or porphyria, hypersensitivity to porphyrins, or photodermatosis
Subjects with use of photosensitizing drugs within 1 week of study start
Subjects with use of topical medications such as corticosteroids, alpha-hydroxyacids or retinoids 2 weeks before study entry
Subjects with systemic steroid therapy within 4 weeks before study entry
Subjects who received previous treatment of target AKs
Subjects with systemic treatment with chemotherapeutic agents, masoprocol (Actinex), immunotherapy, or retinoids within 2 months of study entry
Subjects with prior history of hypersensitivity reactions to lidocaine
Subjects who are unable to understand the protocol or to give informed consent