A Physiological Profile of Recovery From Resistance, Endurance, and Mixed Exercise Types

GlaxoSmithKline (GSK)

Status: Completed

Conditions: Sports Nutritional Sciences

Treatments: Other: High-Intensity stochastic cycling session; Other: Simulated Team sport protocol; Other: Resistance exercise weight training session

Study type: Interventional

Funder types: Industry

Identifiers

NCT03083509

205085

Details and patient eligibility

About

The aim of this study to increase understanding of physiological and functional perturbations following a continuum of exercise stressors.

Full description

This study utilised a between groups design, with a within-groups control. This allowed the within-subject profiling of recovery during both a control and exercise week. This design also allowed each group to perform an ecologically valid exercise session as well as having markers of recovery tailored to the areas of interest specific to each cohort. By having each group perform a non-exercise control week, this gives valuable information on the reliability and smallest worthwhile change for a range of both novel and commonly used recovery markers.

Enrollment: 24 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Demonstrates understanding of the study procedures, restrictions and willingness to participate as evidenced by voluntary written informed consent (see Appendices 2-4) and has received a signed and dated copy of the informed consent form.
• Participant is male
• Good general and mental health as assessed by a health questionnaire and with, in the opinion of the investigator or medically qualified designee ,no clinically significant and relevant abnormalities in medical history or upon oral examination. As well as absence of any condition that would impact on the participant's safety or wellbeing or affect the individual's ability to understand and follow study procedures and requirements.
• Participants will be fully briefed prior to agreeing to participate in the study and the research team will confirm that they are willing, able, and likely to comply with all procedures and complete the study.
• Only the following individuals will be recruited as participants for the study:

Group 1: Resistance trained individuals (≥3 sessions per week for ≥2 years with a minimum of 1 session per week including leg-based exercises).

Group 2: Trained cyclists (competing at a minimum of Category 3 roadracing/ estimated 10 mile TT of <25 minutes and a training history of ≥5 hours per week for ≥2 years).

Group 3: Team sports players (minimum of University 1st team level e.g. soccer, rugby union, rugby league, hockey, and basketball, playing competitively ≥1x per week for ≥2 years).

Exclusion criteria

• Individuals that do not fit the training status inclusion criteria.
• Current use of any non-steroidal anti-inflammatory drugs (NSAID's) or other analgesics for pain relief.
• Participation in another clinical study or receipt of an investigational drug within 30 days of the screening visit.
• Previous participation in this study.
• Recent history (within the last 1 year) of alcohol or other substance abuse.
• An employee of the sponsor or the study site or members of their immediate family.
• Have a heart or any other medical condition that may contra-indicate participants from taking part in high intensity or exhaustive physical activity.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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24 participants in 3 patient groups

Group1 (Resistance trained individuals)

Other group

Description:

Resistance trained individuals (\>3 sessions per weeks for ≥2 years with a minimum of 1 session per week including leg-based exercises)

Treatment:

Other: Resistance exercise weight training session

Group 2 (Trained cyclists)

Other group

Description:

Trained cyclists (competing at a minimum of Category 3 road racing/estimated 10 mile TT of \<25 minutes and a training history of ≥5 hours per week for ≥2 years)

Treatment:

Other: High-Intensity stochastic cycling session

Group 3 (Team sports players)

Other group

Description:

Team sports players (minimum of University 1st team level e.g. soccer, rugby union, rugby league, hockey and basketball, playing competitively ≥1x per week for ≥2 years)

Treatment:

Other: Simulated Team sport protocol