A Pilot Study of a Heparin Dosing Algorithm for Hemodialysis

Vantive Health LLC

Status: Completed

Conditions: Renal Failure Chronic Requiring Hemodialysis

Treatments: Procedure: Heparin dose titration

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01181544

Gambro PI 2012

Details and patient eligibility

About

During hemodialysis treatments, patients receive heparin to prevent clotting. The purpose of this pilot study is to determine if the amount of heparin administered during a patient's hemodialysis can be individualized using an equation for heparin dose adjustment.

Enrollment: 5 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults 18 years of age or older
• Stable hemodialysis prescription prior to study enrollment
• Dialyzing through a native fistula or Gore-Tex graft
• Blood access must be able to provide a blood flow rate of 400 ml/min

Exclusion criteria

• Non-compliance with dialysis
• Hematocrit less than 28%
• Active Infection
• Diagnosis of Heparin-Induced Thrombocytopenia (HIT)

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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5 participants in 1 patient group

Heparin dose titration

Experimental group

Treatment:

Procedure: Heparin dose titration