A Pilot Study of Dietary Chloride Supplementation on Cardiorenal Function in Heart Failure

Yale University

Status: Completed

Conditions: Heart Failure

Treatments: Dietary Supplement: Lysine Chloride

Study type: Interventional

Funder types: Other

Identifiers

NCT02031354

1308012508

Details and patient eligibility

About

The purpose of this study is to determine if administration of supplemental chloride in the form of lysine chloride to patients with congestive heart failure will affect their neurohormonal profile as well as response to diuretics.

Full description

This prospective pilot "pre-post" study was designed to determine if supplementation of sodium free chloride ion as a lysine chloride to patients with heart failure could improve parameters of neurohormonal status and diuretic responsiveness. Volunteers will receive Lysine Chloride 7 grams three times daily for three days. At baseline and then again post lysine chloride patients will undergo sampling of venous blood for determination of neurohormonal parameters in addition to formal diuretic responsiveness testing.

Enrollment: 11 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 years
• Fluency in English
• Heart failure requiring loop diuretic therapy
• Loop diuretic dose ≥ 80mg/day furosemide equivalents
• Stable volume status and diuretic requirement as assessed by treating physician

Exclusion criteria

• Unstable heart failure
• renal replacement therapy or an estimated GFR < 30 ml/min/1.73m2
• Significant bladder dysfunction
• History of hepatic failure
• Pregnancy
• History of hyperinsulinemia/hyperlysinuria

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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11 participants in 1 patient group

Lysine Chloride

Experimental group

Treatment:

Dietary Supplement: Lysine Chloride