A Pilot Study on Whey Protein Supplementation in Non Alcoholic Fatty Liver Disease (PROTOB)

University of Lausanne (UNIL)

Status: Completed

Conditions: Obesity; Non-alcoholic Fatty Liver Disease

Treatments: Dietary Supplement: ProWHEY 94 CFM, SponserR

Study type: Interventional

Funder types: Other

Identifiers

NCT00870077

Protobese

Details and patient eligibility

About

An increase in dietary protein intake has been shown to blunt the increase in intrahepatic fat induced by high fat feeding in healthy individuals. The purpose of this study is to determine if a protein supplementation decreases intrahepatic fat in obese patients with non-alcoholic fatty liver disease.

Full description

12 obese patients will be be treated with a dietary whey protein supplementation over 4 weeks. Their intrahepatic fat content, glucose tolerance, and body weight will be evaluated before and after 4 weeks of supplementation.

Enrollment: 11 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI higher than 35 kg/m2
• age 18-50 years
• sex male or female
• ASAT/ALAT > 1.8

Exclusion criteria

• treatment with hypolemic or antidiabetic agents
• blood glucose > 7 mmol/l
• alcohol intake > 20g/day
• creatinin > 120 umol/l)
• contra-indications to Magnetic resonnance imaging

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

11 participants in 1 patient group

1

Experimental group

Treatment:

Dietary Supplement: ProWHEY 94 CFM, SponserR