A Pilot Study on Whey Protein Supplementation in Non Alcoholic Fatty Liver Disease (PROTOB)

U

University of Lausanne (UNIL)

Status

Completed

Conditions

Obesity
Non-alcoholic Fatty Liver Disease

Treatments

Dietary Supplement: ProWHEY 94 CFM, SponserR

Study type

Interventional

Funder types

Other

Identifiers

NCT00870077
Protobese

Details and patient eligibility

About

An increase in dietary protein intake has been shown to blunt the increase in intrahepatic fat induced by high fat feeding in healthy individuals. The purpose of this study is to determine if a protein supplementation decreases intrahepatic fat in obese patients with non-alcoholic fatty liver disease.

Full description

12 obese patients will be be treated with a dietary whey protein supplementation over 4 weeks. Their intrahepatic fat content, glucose tolerance, and body weight will be evaluated before and after 4 weeks of supplementation.

Enrollment

11 patients

Sex

All

Ages

18 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • BMI higher than 35 kg/m2
  • age 18-50 years
  • sex male or female
  • ASAT/ALAT > 1.8

Exclusion criteria

  • treatment with hypolemic or antidiabetic agents
  • blood glucose > 7 mmol/l
  • alcohol intake > 20g/day
  • creatinin > 120 umol/l)
  • contra-indications to Magnetic resonnance imaging

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

11 participants in 1 patient group

1
Experimental group
Treatment:
Dietary Supplement: ProWHEY 94 CFM, SponserR

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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