A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation (ACCELERATE)

Center for International Blood and Marrow Transplant Research (CIBMTR)

Status and phase: Enrolling; Phase 2

Conditions: Myelofibrosis; MDS (Myelodysplastic Syndrome); Prolymphocyctic Leukemia; Acute Leukemia (Category); CLL (Chronic Lymphocytic Leukemia); Chronic Myelomonocytic Leukemia (CMML); AML (Acute Myelogenous Leukemia); Lymphoma; Acute Lymphoid Leukemia (ALL); Myeloproliferative Neoplasm (MPN); CML (Chronic Myelogenous Leukemia)

Treatments: Drug: Post-transplant Abatacept; Drug: Supportive Care: Growth Factors; Drug: Conditioning Regimen C; Procedure: Supportive Care: Blood Products; Other: Supportive Care: Monitoring and management of CRS; Other: Supportive Care: Lipid elevations; Drug: PTCy (50 mg/kg D3, D4); Drug: Conditioning Regimen B; Other: Prohibited Concomitant Therapy; Drug: Post-transplant Mycophenolate mofetil; Drug: Post-transplant Tacrolimus; Other: Supportive Care: Intravenous immune globulin (IVIG); Drug: Supportive Care: Prophylaxis against infections; Drug: Supportive Care: Seizure prophylaxis; Drug: Conditioning Regimen D; Drug: Conditioning Regimen A; Drug: PTCy (25 mg/kg D3, D4); Drug: Conditioning Regimen E; Drug: Post-transplant Ruxolitinib; Other: Supportive Care: Infection Prophylaxis; Other: Permitted Concomitant Therapy; Other: Study treatment compliance; Procedure: Hematopoietic Cell Transplantation

Study type: Interventional

Funder types: Other; NETWORK; Industry

Identifiers

NCT06859424

ACCELERATE

Details and patient eligibility

About

The purpose of this clinical trial is to compare drug combinations to learn which drugs work best to prevent graft-versus-host-disease (GVHD) in people who have received a stem cell transplant. The source of stem cells is from someone who is not related and has a different blood cell type than the study participant. The researchers will compare the new drug combination to a standard drug combination. They will also learn about the safety of each drug combination.

Participants will:

• Receive the standard or new drug combination after transplant
• Visit the doctor's office for check-ups and tests after transplant that are routine for most transplant patients
• Take surveys about physical and emotional well-being
• Give blood and stool samples.

Full description

This platform protocol will evaluate the safety and efficacy of post-transplant cyclophosphamide (PTCy) based graft-versus-host disease (GVHD) prophylaxis after mismatched unrelated donor (MMUD) hematopoietic cell transplant (HCT). Participants with malignant hematologic diseases eligible per inclusion criteria, receiving MMUD peripheral blood stem cells (PBSCs) after myeloablative conditioning (MAC) or reduced-intensity conditioning (RIC) will be eligible to be enrolled by participating transplant centers. The platform protocol will estimate endpoints and provide a comparator arm for investigational interventional arms (ISAs).

Two investigational ISAs are part of the platform protocol - ACCEL-001 and ACCEL-002. The ISAs describe the specific features of the intervention being studied and treatment of participants assigned to that intervention, the specific target population, sample size required based on comparison to the control arm, specific study objectives, statistical methods for evaluating the interventions, and other specific intervention-related information and assessments. Additional ISAs may be added or closed throughout the lifetime of the trial.

Enrollment: 358 estimated patients

Sex: All

Ages: 18 to 66 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria, MAC RECIPIENTS:

1. Age 18 to < 66 years (chemotherapy-based conditioning) or < 61 years (TBI-based conditioning) at the time of signing informed consent

2. Patient or legally authorized representative has the ability to provide informed consent according to the applicable regulatory and institutional requirements

3. Stated willingness to comply with all study procedures and availability for the duration of the study

4. Planned MAC regimen (see Table 8 in Section 7.4 for allowed MAC regimens)

5. Available partially HLA-MMUD (4/8-7/8 at HLA-A, -B, -C, and -DRB1 is required) with age 16-35

6. Product planned for infusion is MMUD T-cell replete PBSC as allograft

7. HCT-CI < 5 (Appendix H - Hematopoietic Cell Transplant Comorbidity Index Scoring). The presence of prior malignancy will not be used to calculate HCT-CI for this trial, to allow for the inclusion of patients with secondary or therapy-related AML or MDS.

8. One of the following diagnoses:

   1. AML, ALL, or other acute leukemia in first remission or beyond with ≤ 5% marrow blasts and no circulating blasts or evidence of extramedullary disease. Documentation of bone marrow assessment will be accepted within 45 days prior to the anticipated start of conditioning.
   2. Patients with MDS with no circulating blasts and with < 10% blasts in the bone marrow (higher blast percentage allowed in MDS due to lack of differences in outcomes with < 5% vs 5-10% blasts in MDS). Documentation of bone marrow assessment will be accepted within 45 days prior to the anticipated start of conditioning.

9. Cardiac function: Left ventricular ejection fraction ≥ 45% based on most recent echocardiogram or multi-gated acquisition scan (MUGA) results

10. Estimated creatinine clearance ≥ 45mL/min calculated by equation

11. Pulmonary function: diffusing capacity of the lungs for carbon monoxide (DLCO) corrected for hemoglobin ≥ 50% and forced expiratory volume in first second (FEV1) predicted ≥ 50% based on most recent PFT results

12. Liver function acceptable per local institutional guidelines

13. KPS of ≥ 70% (Appendix I - Performance Status)

Inclusion Criteria, RIC/NMA RECIPIENTS:

1. Age ≥ 18 years at the time of signing informed consent

2. Patient or legally authorized representative has the ability to provide informed consent according to the applicable regulatory and local institutional requirements

3. Stated willingness to comply with all study procedures and availability for the duration of the study

4. Planned NMA/RIC regimen (see

5. Table 9 in Section 7.4 for allowed NMA/RIC regimens)

6. Available partially HLA-MMUD (4/8-7/8 at HLA-A, -B, -C, and -DRB1 is required) with age 16-35

7. Product planned for infusion is MMUD T-cell replete PBSC allograft

8. One of the following diagnoses:

   1. Patients with acute leukemia or chronic myeloid leukemia (CML) with no circulating blasts, no evidence of extramedullary disease, and with < 5% blasts in the bone marrow. Documentation of bone marrow assessment will be accepted within 45 days prior to the anticipated start of conditioning.
   2. Patients with MDS with no circulating blasts and with < 10% blasts in the bone marrow (higher blast percentage allowed in MDS due to lack of differences in outcomes with < 5% vs 5-10% blasts in MDS.) Documentation of bone marrow assessment will be accepted within 45 days prior to the anticipated start of conditioning.
   3. Patients with chronic lymphocytic leukemia (CLL) or other leukemias (including prolymphocytic leukemia) with chemosensitive disease at time of transplantation.
   4. Higher-risk chronic myelomonocytic leukemia (CMML) according to CMML-specific prognostic scoring system or high-risk MDS/myeloproliferative neoplasms (MPN) not otherwise specified are eligible, provided there is no evidence of high-grade bone marrow fibrosis or massive splenomegaly at the time of enrollment.
   5. Patients with lymphoma with chemosensitive disease at the time of transplantation.
   6. Patients with primary myelofibrosis or myelofibrosis secondary to essential thrombocythemia, polycythemia vera or MDS with grade 4 fibrosis.

9. Cardiac function: Left ventricular ejection fraction ≥ 40% based on most recent echocardiogram or MUGA results with no clinical evidence of heart failure

10. Estimated creatinine clearance ≥ 45mL/min calculated by equation

11. Pulmonary function: DLCO corrected for hemoglobin ≥ 50% and FEV1 predicted ≥ 50% based on most recent PFT results

12. Liver function acceptable per local institutional guidelines

13. KPS of ≥ 60% (Appendix I - Performance Status)

Exclusion Criteria:

1. Suitable HLA-matched related or 8/8 high-resolution matched unrelated donor available
2. Subject unwilling or unable to give informed consent, or unable to comply with the protocol including required follow-up and testing
3. Subjects with a prior allogeneic transplant
4. Subjects with an autologous transplant within the past 3 months
5. Subjects who are breastfeeding or pregnant
6. Uncontrolled bacterial, viral or fungal infection at the time of the transplant preparative regimen
7. Concurrent enrollment on a GVHD prevention clinical trial
8. Subjects who undergo desensitization to reduce anti-donor HLA antibody levels prior to transplant
9. Patients who are HIV-positive with persistently positive viral load. HIV-infected patients on effective anti-retroviral therapy (ART) with undetectable viral load within 6 months are eligible for this trial. Patients with well-controlled HIV are eligible provided resistance panels are negative, the patient is compliant with ART, and their disease remains well controlled.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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358 participants in 3 patient groups

Control/SOC

Experimental group

Description:

Shared comparator control group

Treatment:

Other: Permitted Concomitant Therapy

Other: Study treatment compliance

Other: Permitted Concomitant Therapy

Other: Prohibited Concomitant Therapy

Other: Supportive Care: Infection Prophylaxis

Drug: Conditioning Regimen E

Drug: Conditioning Regimen A

Other: Prohibited Concomitant Therapy

Drug: Post-transplant Mycophenolate mofetil

Drug: Conditioning Regimen B

Drug: PTCy (50 mg/kg D3, D4)

Other: Supportive Care: Monitoring and management of CRS

Procedure: Supportive Care: Blood Products

Procedure: Hematopoietic Cell Transplantation

Drug: Supportive Care: Seizure prophylaxis

Drug: Conditioning Regimen D

Other: Permitted Concomitant Therapy

Other: Supportive Care: Intravenous immune globulin (IVIG)

Drug: Post-transplant Tacrolimus

Other: Prohibited Concomitant Therapy

Drug: Supportive Care: Growth Factors

Drug: Conditioning Regimen C

ACCEL-001

Experimental group

Description:

Intervention 1

Treatment:

Other: Permitted Concomitant Therapy

Other: Study treatment compliance

Other: Permitted Concomitant Therapy

Other: Prohibited Concomitant Therapy

Other: Supportive Care: Infection Prophylaxis

Drug: Conditioning Regimen E

Drug: PTCy (25 mg/kg D3, D4)

Drug: Conditioning Regimen A

Other: Prohibited Concomitant Therapy

Drug: Conditioning Regimen B

Other: Supportive Care: Monitoring and management of CRS

Procedure: Supportive Care: Blood Products

Drug: Post-transplant Abatacept

Procedure: Hematopoietic Cell Transplantation

Drug: Supportive Care: Seizure prophylaxis

Drug: Conditioning Regimen D

Other: Permitted Concomitant Therapy

Other: Supportive Care: Intravenous immune globulin (IVIG)

Drug: Post-transplant Tacrolimus

Other: Prohibited Concomitant Therapy

Drug: Supportive Care: Growth Factors

Drug: Conditioning Regimen C

ACCEL-002

Experimental group

Description:

Intervention 2

Treatment:

Other: Permitted Concomitant Therapy

Other: Study treatment compliance

Other: Permitted Concomitant Therapy

Other: Prohibited Concomitant Therapy

Other: Supportive Care: Infection Prophylaxis

Drug: Conditioning Regimen E

Drug: PTCy (25 mg/kg D3, D4)

Drug: Conditioning Regimen A

Drug: Supportive Care: Prophylaxis against infections

Other: Prohibited Concomitant Therapy

Drug: Post-transplant Mycophenolate mofetil

Drug: Conditioning Regimen B

Other: Supportive Care: Lipid elevations

Other: Supportive Care: Monitoring and management of CRS

Procedure: Supportive Care: Blood Products

Procedure: Hematopoietic Cell Transplantation

Drug: Post-transplant Ruxolitinib

Drug: Supportive Care: Seizure prophylaxis

Drug: Conditioning Regimen D

Other: Permitted Concomitant Therapy

Other: Supportive Care: Intravenous immune globulin (IVIG)

Drug: Post-transplant Tacrolimus

Drug: Supportive Care: Prophylaxis against infections

Other: Prohibited Concomitant Therapy

Drug: Supportive Care: Growth Factors

Drug: Conditioning Regimen C