A Postoperative Sore Throat After Lumbar Spine Surgery in the Prone Position

Yeungnam University College of Medicine

Status: Unknown

Conditions: Post Operative Sore Throat

Treatments: Drug: dexmedetomidine infusion; Drug: remifentanil infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT05345574

YUMC 2018-09-029

Details and patient eligibility

About

This study was performed to compare the effect of dexmedetomidine and remifentanil on the incidence and severity of postoperative sore throat in patients undergoing spinal surgery in the prone position who are at risk of developing postoperative sore throat.

Enrollment: 104 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. American Society of Anesthesiologists (ASA) physical status classification I and II
2. Undergoing lumbar spine surgery in prone position

Exclusion criteria

1. Pre-existing sore throat, hoarseness, or upper respiratory tract infection
2. Allergy to the study drugs
3. Anticipated difficult airways
4. More than two attempts at intubation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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104 participants in 2 patient groups

dexmedetomidine infusion group

Active Comparator group

Description:

dexmedetomidine infusion (loading dose of 1 ㎍/kg over 10 min and continuous infusion of 0.3-0.6 ㎍/kg/h) during the surgery

Treatment:

Drug: dexmedetomidine infusion

remifentanil infusion group

Active Comparator group

Description:

remifentanil of 0.05 ㎍/kg/h during induction, followed by remifentanil infusion (0.05-0.3 ㎍/kg/h) during the surgery

Treatment:

Drug: remifentanil infusion