A Prediction Model of Prolonged Mechanical Ventilation Following Acute Type A Aortic Dissection Surgery

China-Japan Friendship Hospital

Status: Not yet enrolling

Conditions: Acute Type A Aortic Dissection

Study type: Observational

Funder types: Other

Identifiers

NCT06929780

2025-zxm-01

Details and patient eligibility

About

The goal of this observational study is to develop and validate a predictive model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery.

The main questions it aims to answer are:

1. To validate the predictive performance of the model for PMV after ATAAD surgery
2. To assess the proportion of PMV among patients undergoing ATAAD surgery
3. To evaluate the ICU length of stay and operative mortality in patients with PMV following ATAAD surgery

Enrollment: 1,400 estimated patients

Sex: All

Ages: 18 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 years;
• Diagnosis of acute type A aortic dissection (ATAAD) confirmed by computed tomography angiography and echocardiography;
• Patients who underwent aortic surgery requiring cardiopulmonary bypass (CPB), were admitted to the surgical intensive care unit (SICU), and received mechanical ventilation.

Exclusion criteria

• Reintubation;
• Intraoperative death or failure to survive beyond 72 hours postoperatively;
• Pregnancy;
• Severe comorbidities (e.g., lung cancer);
• Missing critical outcome data (e.g., short-term mortality, mechanical ventilation duration, reintubation).

Trial design

1,400 participants in 2 patient groups

Development cohort

Description:

As the development cohort, this cohort retrospectively enrolled approximately 1000 postoperative patients undergoing acute type A aortic dissection (ATAAD) surgery to establish a clinical model for predicting the risk of prolonged mechanical ventilation (PMV) after ATAAD surgery.This cohort will also be utilized to analyze the risk factors for PMV following ATAAD surgery and their impact on clinical outcomes.

Validation cohort

Description:

As the validation cohort, this cohort retrospectively enrolled approximately 400 patients (from January 2024 to December 2024) who underwent ATAAD surgery to validate the predictive performance of the model.