A-prf,Nanochitosan Combined With A-prf Compared to Chitosan for Symptomatic Irreversible Pulpitis of Mature Teeth

Future University in Egypt

Status: Enrolling

Conditions: Pulpitis - Irreversible

Treatments: Procedure: PULPOTOMY OF MATURE PERMENANT TEETH

Study type: Interventional

Funder types: Other

Identifiers

NCT06438523

29

Details and patient eligibility

About

Clinical and radiographic assessment of A-prf,A-prf combined with nanochitosan compared to chitosan for symptomatic irreversible pulpits in lower permanent first molar

Full description

3 groups are allocated using : Aprf Aprf combined with nanochitosan Chitosan

Each group will be subjected to tests:

Tooth sensibility via EPT (electrical pulp tester)and thermal test Radiolucency in digital radiograph Pain in NRS(6-12-24-72h)for 1 week

Enrollment: 30 estimated patients

Sex: All

Ages: 15 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients suffering from Symptomatic irreversible pulpitis in mature mandibular molars only will be involved.

  • Patients of either gender aged from 15-30.
  • Tooth should give positive response to cold test.
  • Haemostasias should be achieved after total pulpotomy.
  • The tooth is restorable and free from advanced periodontal disease, cracks and splits.
  • Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
  • Patients who will agree to the consent and will commit to follow-up period.
  • Patients with mature root.
  • Patients with no internal or external resorption and no periapical lesions.
  • Soft tissues around the tooth are normal with no swelling or sinus tract.

Exclusion criteria

• Patients with immature roots.

  • Haemostasias after 10 minutes can not be controlled after total pulpotomy
  • Patients with any systemic disease that may affect normal healing.
  • Patients with periapical lesions or infections.
  • Pregnant females.
  • Patients who could/would not participate in a 6 months follow-up.
  • Patients with fistula or swelling
  • Patients with necrotic pulp.
  • Patients with old age.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 3 patient groups

Advanced Platelet rich fibrin,A-prf,A-PRF scaffold

Experimental group

Description:

A-PRF will be prepared according to Choukroun's technique by drawing whole blood from the median cubital vein into a 10 ml plain plastic test tubes (non-citrated) without the addition of an anticoagulant reagent . To prevent the blood from coagulating, it will be centrifuged immediately using a table top centrifuge at 1500 rpm for 14 minute.

Treatment:

Procedure: PULPOTOMY OF MATURE PERMENANT TEETH

A-prf mixed with nano chitosan

Experimental group

Description:

A-PRF will be prepared according to Choukroun's technique by drawing whole blood from the median cubital vein into a 10 ml plain plastic test tubes (non-citrated) without the addition of an anticoagulant reagent . To prevent the blood from coagulating, it will be centrifuged immediately using a table top centrifuge at 1500 rpm for 14 minute then mixed with nanochitosan

Treatment:

Procedure: PULPOTOMY OF MATURE PERMENANT TEETH

chitosan

Experimental group

Description:

he access cavity will be prepared up to the level of pulp chamber floor using sterile round diamond bur size 1 in high-speed hand piece with coolant.Once the pulp has been reached, a sharp sterile excavator should be used to remove the pulp tissue to the level of the radicular/root canal orifices then chitosan will be applied

Treatment:

Procedure: PULPOTOMY OF MATURE PERMENANT TEETH