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A Progressive Resistance Training Program in Patients With Haemophilia

U

University of Valencia

Status

Completed

Conditions

Haemophilia

Treatments

Other: Progressive resistance training
Other: Normal daily activities

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT02781233
H15-29504

Details and patient eligibility

About

This study evaluates the clinical impact of a progressive resistance training program in adults patients with haemophilia

Full description

The training program aims improving muscular strength and endurance in the relevant muscles and joints (knee, elbow, ankle, shoulder and hip) in order to improve the quality of life in the patients.

Enrollment

20 patients

Sex

Male

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • diagnosis of haemophilia A or B
  • willingness to exercise twice a week during the training program and to complete the pre- and post-program evaluations
  • approval by their hematologist to participate in the exercise program
  • age between 18 and 60 years
  • informed consent signed.

Exclusion criteria

  • the inability to attend exercise sessions at least twice a week for 6 consecutive weeks
  • non adherence to instruction on proper exercise technique
  • surgical procedures performed 6 weeks prior to or during the exercise program
  • participation in any other form of exercise, including rehabilitation, during the study; (5) changes in medication during the study
  • a major bleeding episode that posed a risk or prevented exercise
  • History of FVIII inhibitor (titer ≥ 0.6 BU [Bethesda unit]) or detectable FVIII inhibitors at screening (titer ≥ 0.4 BU)
  • Another haemostatic defect
  • Need for major surgery
  • Withdrawal of informed consent

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

20 participants in 2 patient groups, including a placebo group

Training group
Experimental group
Description:
Each subject will participate in 2 sessions each week during 8 weeks, with 3 days of difference (rest) between the sessions.
Treatment:
Other: Progressive resistance training
Control group
Placebo Comparator group
Description:
Usual daily activities
Treatment:
Other: Normal daily activities

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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