A Proof-of-Concept Study of Danicopan for 6 Months of Treatment in Participants With C3 Glomerulopathy (C3G)

Alexion Pharmaceuticals

Status and phase: Completed; Phase 2

Conditions: C3 Glomerulopathy; Dense Deposit Disease; C3 Glomerulonephritis

Treatments: Drug: Danicopan; Drug: Placebo

Study type: Interventional

Funder types: Industry

Identifiers

NCT03369236

ACH471-204

2017-000663-33 (EudraCT Number)

Details and patient eligibility

About

The primary purpose of this proof-of-concept clinical study was to evaluate the efficacy and safety of the study drug, ACH-0144471 (also known as danicopan and ALXN2040), in participants with C3G who also had significant proteinuria attributable to C3G.

Enrollment: 13 patients

Sex: All

Ages: 17 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Key Inclusion Criteria:

• Had biopsy-confirmed primary C3G
• Had clinical evidence of ongoing disease based on significant proteinuria, attributable to C3G disease in the opinion of the Principal Investigator (PI), and present prior to study entry and confirmed during Screening
• Was willing to comply with vaccination requirements.

Key Exclusion Criteria:

• Had a history or presence of any clinically relevant co-morbidities that would make the participant inappropriate for the study
• Had ever received danicopan
• Had more than 50% fibrosis or more than 50% of glomeruli with cellular crescents on the pre-treatment renal biopsy
• Had an estimated glomerular filtration rate <30 milliliters/minute/1.73 meters squared at the time of screening or at any time over the preceding 4 weeks
• Was a renal transplant recipient or receiving renal replacement therapy
• Had a history of a major organ transplant or hematopoietic stem cell/marrow transplant
• Had evidence of monoclonal gammopathy of unclear significance, infections, malignancy, autoimmune diseases, or other conditions to which C3G is secondary
• Had other renal diseases that would interfere with interpretation of the study
• Had been diagnosed with or showed evidence of hepatobiliary cholestasis
• Females who were pregnant, nursing, or planning to become pregnant during the study or within 90 days of study drug administration
• Had a history of febrile illness, a body temperature >38°Celsius, or other evidence of a clinically significant active infection, within 14 days prior to study drug administration
• Had evidence of human immunodeficiency virus, hepatitis B infection, or active hepatitis C infection at Screening
• Had laboratory abnormalities at screening that, in the opinion of the PI, would make the participant inappropriate for the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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13 participants in 2 patient groups, including a placebo group

Danicopan (Double-blind Treatment Period), Followed by Danicopan (Open-label Extension Period)

Active Comparator group

Description:

Danicopan was administered at a starting dose of 100 milligrams (mg) 3 times daily (TID) for the first 2 weeks, then dosage was to be increased to 200 mg TID for the remainder of the 6-month treatment period. All participants who completed the double-blind treatment period were enrolled in the open-label extension period and were to receive danicopan 200 mg TID.

Treatment:

Drug: Danicopan

Placebo (Double-blind Treatment Period), Followed by Danicopan (Open-label Extension Period)

Placebo Comparator group

Description:

Placebo was administered TID during the 6-month treatment period. All participants who completed the double-blind treatment period were enrolled in the open-label extension period and were to receive danicopan 200 mg TID.

Treatment:

Drug: Placebo

Drug: Danicopan