A Prospective Cohort of Pulmonary Ground Glass Nodules Patients With Family History. (GGN-F)

Guangdong Provincial People's Hospital (Guangdong Provincial Academy of Medical Sciences)

Status: Unknown

Conditions: Lung Neoplasms; Family Research

Study type: Observational

Funder types: Other

Identifiers

NCT04220268

GGN-family

Details and patient eligibility

About

The aim of the present prospective cohort study (GGN-F) is to study the family aggregation of pulmonary ground glass nodules via the questionnaire survey and to investigate the underlying genetic mechanism via the biobank.

Full description

In recent years, with the development of low-dose chest CT screening, more and more ground glass nodules have been found. Meanwhile, presenting as Ground-glass nodule (GGN), the early-stage lung adenocarcinoma patients with lung cancer family history have been emerging increasing in recent years in East Asian.

This prospective cohort study, with both a cross-sectional and a longitudinal part, will include patients with pulmonary ground glass nodule, which were proven malignant disease.

All participants will be asked to complete questionnaire to build the clinical database of GGN patients with detailed family history. Furthermore, blood and surgical tumor samples will be collected as a specific biobank. And the blood samples of other family members of participants will be collected, with their consent and knowledge.

Enrollment: 600 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. patients with informed consent;
2. patients with pulmonary ground glass nodule.
3. pathological proved early stage lung cancer.

Exclusion criteria

1.not included in the inclusion criteria

Trial design

600 participants in 1 patient group

Participants

Description:

All the patients with proved malignant ground glass nodule will be enrolled.