A Prospective Cohort Study for Patients With Adrenal Diseases

Seoul National University

Status: Invitation-only

Conditions: Primary Hyperaldosteronism; Adrenocortical Carcinoma; Adrenal Adenoma; Cushing Syndrome; Adrenal Incidentaloma; Pheochromocytoma

Treatments: Other: Hormone study and Imaging study

Study type: Observational

Funder types: Other

Identifiers

NCT03474237

1801-010-911

Details and patient eligibility

About

The purpose of this study is to investigate the pathologic features, complications, and prognostic factors of functioning adrenal adenoma and suggest follow-up algorithms for adrenal incidentaloma.

Full description

The investigators will recruit 150 patients annually for 10 years (adrenal incidentaloma 100 patients, pheochromocytoma 15 patients, primary aldosteronism 25 patients, adrenal cushing syndrome 10 patients, adrenocortical carcinoma 2 patients) and perform hormonal, biochemical, imaging exam according to each disease's clinical guidelines. Based on this, the investigators will identify pathologic features, complications, and prognostic factors of each disease.

Enrollment: 1,500 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults, male or female aged 19 years or older
• newly diagnosed with adrenal disease such as adrenal incidentaloma, pheochromocytoma, primary aldosteronism, adrenal cushing syndrome, adrenocortical carcinoma

Exclusion criteria

• previous or current history of adrenal diseases
• using oral or intravenous steroids
• history of major depressive disorder
• history of chronic alcoholics
• history of any cancer with suspicious adrenal metastasis
• those with acute illness (ex- patients with acute coronary syndrome within 4 weeks, acute febrile disease)

Trial design

1,500 participants in 5 patient groups

Non-functioning adrenal incidentaloma

Description:

patients who were diagnosed with non-functioning adrenal incidentaloma on computed tomography or magnetic resonance imaging

Treatment:

Other: Hormone study and Imaging study

Pheochromocytoma

Description:

patients who were diagnosed with pheochromocytoma biochemically or histologically

Treatment:

Other: Hormone study and Imaging study

Primary aldosteronism

Description:

patients who were diagnosed with primary aldosteronism by saline loading test

Treatment:

Other: Hormone study and Imaging study

Adrenal cushing syndrome

Description:

patients who were diagnosed with adrenal cushing syndrome by dexamethasone suppression test and 24 urine free cortisol test.

Treatment:

Other: Hormone study and Imaging study

Adrenocortical carcinoma

Description:

patients who were diagnosed with adrenocortical carcinoma by imaging study or histologic exam

Treatment:

Other: Hormone study and Imaging study