A Prospective Cohort Study on the Comorbid Depression in Patients With Newly-diagnosed Epilepsy

Fudan University

Status: Unknown

Conditions: Epilepsy

Treatments: Other: psychology therapy

Study type: Observational

Funder types: Other

Identifiers

NCT04517058

NEWEpiDp

Details and patient eligibility

About

Epilepsy is a chronic brain disease with recurrent seizures and the comorbidity of psychiatric diseases are very common. The prevalence of depression in patients with refractory epilepsy is about 60%. However, the early diagnosis is usually difficult due to the unclear mechanism and untypical clinical symptoms, and there are no extremely effective treatments for depression in patients with epilepsy until now. In this prospective, multi-center, cohort study, we aim to investigate and screen two different types of depression ("cognitive" and "somatic") in patients with epilepsy by using the combination of regular moods evaluating scales and heart rate variability instrument. The intervening methods of combining transcranial direct current stimulation (tDCS) and serotonin re-uptake inhibitors (SSRIs) are used to treat the patients with comorbidity of epilepsy and depression.

Full description

Epilepsy is a chronic brain disease with recurrent seizures and the comorbidity of psychiatric diseases are very common. The prevalence of depression in patients with refractory epilepsy is about 60%. However, the early diagnosis is usually difficult due to the unclear mechanism and untypical clinical symptoms, and there are no extremely effective treatments for depression in patients with epilepsy until now. In this prospective, multi-center, cohort study, we aim to investigate and screen two different types of depression ("cognitive" and "somatic") in patients with epilepsy by using the combination of regular moods evaluating scales and heart rate variability instrument. The intervening methods of combining transcranial direct current stimulation (tDCS) and serotonin re-uptake inhibitors (SSRIs) are used to treat the patients with comorbidity of epilepsy and depression. And resting-state functional MRI will be conducted in patients with the comorbidity of epilepsy and depression before and after the combing treatment of tDCS and SSRIs.

Enrollment: 300 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• meeting the definition of epilepsy according to the new definition issued by ILAE in 2014
• not using antidepressants
• acquiring informed consents

Exclusion criteria

• patients with severe psychiatric symptoms;
• progressive brain diseases
• malignant tumors
• severe cognitive declines

Trial design

300 participants in 2 patient groups

epilepsy patients with depression group

Description:

the score of HAMD-17\>7

Treatment:

Other: psychology therapy

epilepsy patients without depression group

Description:

the score of HAMD-17≤7