A Prospective Controlled Study of Serum suPAR in the CsA-treated FSGS Patients (SuparSDRF)

Guangdong Provincial People's Hospital (Guangdong Provincial Academy of Medical Sciences)

Status: Unknown

Conditions: FSGS

Study type: Observational

Funder types: Other

Identifiers

NCT01468493

GGH-1-1

Details and patient eligibility

About

The purpose of this study is to determine whether the improved responsiveness to treatment achieved by CsA in patients with steroid-resistant or steroid-dependent FSGS could be explained by CsA's inhibitory action on the circulating suPAR expression.

Enrollment: 90 estimated patients

Sex: All

Ages: 14 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age at entry is between 14 and 70 years
• biopsy-proven primary FSGS
• proteinuria >=3 g/day
• without corticosteroids or CsA treatment before entry

Exclusion criteria

• Chronic Inflammatory Diseases
• malignant tumor
• diabetes mellitus
• contraindications for the treatment of corticosteroids or CsA treatment
• untolerate to or unwilling to accept corticosteroids or CsA treatment

Trial design

90 participants in 3 patient groups

steroid-sensitive FSGS

steroid-dependent and resistant FSGS

Healthy volunteers