A Prospective, Single Blinded Study for Predicting Colon Polyp Histology With Narrow Band Imaging (NBI)

Midwest Biomedical Research Foundation

Status: Unknown

Conditions: Adenomatous Polyp; Colonoscopy; Neoplastic

Treatments: Other: Narrow Band Imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT00613262

00371

AR0002

Details and patient eligibility

About

The investigators hypothesize that NBI will have a high accuracy in predicting polyp histology real time during a colonoscopy by visualization of the surface mucosal and vascular patterns. Aim#1: To determine the sensitivity, specificity and accuracy of NBI and standard white light colonoscopy for predicting polyp histology by evaluating the surface mucosal and vascular patterns during colonoscopy. Aim#2: To determine the inter-observer agreement between investigators for the recognition of various polyp patterns.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• referral for screening or surveillance colonoscopy
• the ability to provide informed consent

Exclusion criteria

• prior surgical resection of any portion of colon
• prior history of colon cancer
• history of inflammatory bowel disease
• use of anti-platelet agents or anticoagulants that precludes removal of polyps during the procedure
• poor general condition or any other reason to avoid prolonged procedure time
• history of polyposis syndrome or Hereditary Non-polyposis colon cancer
• inability to give informed consent

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind