Clinical Study to Evaluate the Efficacy and Safety of Nab-Paclitaxel Combined With Cisplatin and Sintilimab in Neoadjuvant Treatment of Locally Advanced Cervical Cancer

Chinese Academy of Medical Sciences & Peking Union Medical College

Status and phase

Not yet enrolling

Phase 2

Conditions

Cervical Carcinoma

Treatments

Drug: Sintilimab

Radiation: Concurrent chemo-radiotherapy

Study type

Interventional

Funder types

Other

Identifiers

NCT07088731

25/275-5221

Details and patient eligibility

About

For locally advanced cervical cancer, there are two main treatment options:

One is radical chemoradiotherapy (a combination of radiotherapy and chemotherapy aimed at curing the disease).

The other is having neoadjuvant treatment first (treatment given before the main surgery to shrink the tumor) followed by radical surgery.

So far, there's no clear answer on which of these two options is better. In general, cervical cancer responds well to immunotherapy. But we still don't know for sure if adding immunotherapy to neoadjuvant chemotherapy can improve the treatment effect for locally advanced cervical cancer, or even make it better than radical chemoradiotherapy.

This study aims to compare the effects of two approaches: radical chemoradiotherapy versus neoadjuvant chemotherapy plus immunotherapy followed by surgery.

Enrollment

180 estimated patients

Sex

Female

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aged ≥ 18 years and ≤ 70 years;
Cervical cancer with pathological types being squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma;
Staged IB3 or IIA2 according to the FIGO 2018 staging system, as assessed by the investigator;
ECOG performance status of 0-2, or KPS score ≥ 70;
Expected survival time of more than 3 months;
Having at least one measurable lesion in accordance with RECIST 1.1;
Laboratory test results meeting the following criteria without drug intervention:
1. Hemoglobin ≥ 90 g/dl, neutrophil count ≥ 1.5 × 10⁹/L, platelet count ≥ 100 × 10⁹/L;
2. Creatinine ≤ 1.5 times the upper limit of normal range;
3. Total bilirubin, alanine transaminase (ALT), and aspartate transaminase (AST) < 2 times the upper limit of normal;
Postmenopausal, or reproductive-aged women who meet all the following conditions: non-lactating, not pregnant, and able to use effective contraceptive measures during the study treatment period;
Voluntarily participating in this study and signing the informed consent form.

Exclusion criteria

Participated in other clinical trials within 30 days before receiving the first dose of chemotherapy drugs or during the treatment period.
Previously received any other anti-tumor treatment for cervical cancer.
Non-HPV-related cervical cancer.
Needing to receive other anti-tumor treatments during the study treatment period.
Patients with known allergies to the active ingredients of the study drugs or their excipients.
Diagnosed with other malignant tumors in the past 5 years (except those judged to be cured by the investigator).
Active infections requiring systemic treatment.
Positive for human immunodeficiency virus (HIV) antibody.
Positive for hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) antibody.
Peripheral neuropathy with a grade of ≥ 2 according to the NCI-CTCAE (Version 5.0).
Concurrent diseases or abnormal test results that interfere with the subject's ability to receive anti-tumor treatment as judged by the investigator, such as the estimated inability of the subject to tolerate at least 2 cycles of neoadjuvant chemotherapy plus surgery or concurrent chemoradiotherapy, etc.