A Prospective Study of Expression Profiling-based Assessment of the Efficacy of Neoadjuvant Therapy for Rectal Cancer

Shanghai Minimally Invasive Surgery Center

Status: Not yet enrolling

Conditions: Neoadjuvant Therapy; Rectal Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT06746298

RNA-seq-Neo

Details and patient eligibility

About

This is a prospective study of expression profiling-based assessment of the efficacy of neoadjuvant therapy for rectal cancer.

Enrollment: 118 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 years, male or infertile female
• Patients with rectal adenocarcinoma diagnosed by colonoscopic biopsy
• Neoadjuvant therapy according to guideline recommendations
• Endoscopic biopsy with access to biopsy tissue for subsequent RNA-seq testing
• Patients who do not have a combination of primary malignant tumors elsewhere.
• Patients who understand the purpose of the trial, participate voluntarily and sign an informed consent form.

Exclusion criteria

• Samples are not collected, stored, or processed in accordance with specified requirements
• Sample does not meet the requirements for subsequent RNA-seq testing
• Cases enrolled with a subsequent diagnosis other than rectal adenocarcinoma.
• The patient refuses or is unable to complete the entire neoadjuvant treatment
• Lack of post-neoadjuvant imaging results and lack of routine postoperative pathology results.
• Other patients who, in the judgment of the investigator, do not meet the enrollment requirements

Trial design

118 participants in 1 patient group

Rectal cancer patients receiving neoadjuvant therapy