A Prospective Study of the Effect of Modified Colonoscopy Bowel Preparation Program on Intestinal Cleaning, Examination and Disease in Patients With Inflammatory Bowel Disease

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Enrolling

Conditions: Inflammatory Bowel Diseases

Treatments: Drug: Polyethylene Glycols

Study type: Interventional

Funder types: Other

Identifiers

NCT05485103

ZS-3300

Details and patient eligibility

About

The purpose of this study is to investigate the effect of modified colonoscopy bowel preparation method compared with traditional method on bowel cleansing effect, colonoscopy examination effect and clinical condition of inflammatory bowel disease patients. Risk factors affecting the quality of bowel preparation will also be studied.

Enrollment: 144 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis: inflammatory bowel disease (IBD) patients, including ulcerative colitis (UC) and Crohn's disease (CD), have colonic involvement.
• Patients and/or family members can understand the study protocol and are willing to participate in the study and provide informed consent in writing.

Exclusion criteria

• The diagnosis is not definite.
• Toxic megacolon, gastrointestinal perforation or other acute abdominal diseases; Patients with gastrointestinal bleeding with unstable vital signs.
• Patients after colon surgery.
• Serious underlying diseases, organ failure, or inability to cooperate with colonoscopy for other reasons.
• Patients can not cooperate with the use of polyethylene glycol or glycerin enema.
• Patients or family members cannot understand the conditions and objectives of this study.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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144 participants in 2 patient groups

Modified bowel preparation method group

Experimental group

Description:

One day before the colonoscopy, only asol (or other intestinal nutrient solution) was taken. On the examination day (4 hours before), 1 bag of polyethylene glycol solution + (2 hours before) glycerin enema 110ml was taken

Treatment:

Drug: Polyethylene Glycols

Traditional bowel preparation method group

Active Comparator group

Description:

Low residue diet 2 days before the colonoscopy, take 2 bags of polyethylene glycol solution the night before the examination and 1 bag of which on the examination day (4 hours before)

Treatment:

Drug: Polyethylene Glycols