A Prospective Study on Predictive Value of Non-Invasive Atherosclerotic Measurements in Elderly Chinese

Tianjin Medical University

Status: Unknown

Conditions: Atherosclerosis; Cardiovascular Disease

Treatments: Other: Cardiovascular events

Study type: Observational

Funder types: Other

Identifiers

NCT01208116

B2009A055

Details and patient eligibility

About

The purpose of this study is to determine whether non-invasive atherosclerotic measurements (baPWV, IMT, FMD, CACS, ABI) are valuable predictors for cardiovascular events in elderly. At inception, routine physical examination and non-invasive atherosclerotic measurements will conducted on all participants. Then they will be followed prospectively for at least 2 years. All cardiovascular and other health events will be recorded.

Full description

Cardiovascular disease is the most common cause of morbidity and mortality in the world, especially in elderly. Conventional risk factors are widely used in clinical practice, but it is inadequate and inaccurate due to no direct evaluation of artery. However, invasive method, it is difficult to be applied in atherosclerosis screening and only used in advanced institutions, is expensive and unacceptable. We are trying to assess the value of noninvasive measurements in predicting cardiovascular events.

Five invasive methods will be applied in the study, including

• brachial-ankle Pulse Wave Velocity(baPWV)
• Carotid Intimal-Medial Thickness(CIMT)
• Flow Mediated Dilation(FMD)
• Ankle-Brachial Index(ABI)
• Coronary Artery Calcification Score(CACS)

These indices represent not only different phase of atherosclerosis, but also various sections and arterial layers.

Enrollment: 1,290 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Chinese, age>=60, no gender restriction.
• To be able to apply the measurement mentioned above.
• Medical history are maintained precisely.
• Tianjin Medical University General Hospital is the participants' designated hospital by national health authority.

Exclusion criteria

• Systemic inflammation.
• Malignant tumor
• Chronic lung disease
• Liver disease
• Aortic aneurysm

Trial design

1,290 participants in 1 patient group

Subgroups

Description:

According to the demographic features, subjects may be divided into some subgroups.

Treatment:

Other: Cardiovascular events